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Open AccessReduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment
We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients...
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Article
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03087-6
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WNT Signalling in Lung Physiology and Pathology
The main physiological function of the lung is gas exchange, mediated at the interface between the alveoli and the pulmonary microcapillary network and facilitated by conducting airway structures that regulate...
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Article
Inhibition of LTβR signalling activates WNT-induced regeneration in lung
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the development of tertiary lymphoid structures1,2, which are associated with severe chronic inflammatory diseases that span several organ...
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Article
Open AccessAlveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptiona...
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Open AccessDifferential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to f...
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Article
Open AccessDynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis
Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (H...
