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Chapter
Mammary-Derived Growth Inhibitor (MDGI)
In contrast to the steadily increasing number of growth factors capable of stimulating cells to synthesize DNA and to divide, very little is known about their potential antagonists, which are supposed to contr...
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Article
Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis
Fibroblast growth factors (FGF)-1 and -2 are found in most embryonic and adult normal and tumor tissues, where they are immobilized in the extracellular matrix (EM). Mobilization of these FGFs is part of a tig...
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Article
Breast cancer growth inhibition by delivery of the MDGI-derived peptide P108
Mammary derived growth inhibitor (MDGI) is a member of the family of cytoplasmic fatty acid binding proteins (FABPs), which bind hydrophobic ligands such as fatty acids, retinoids, eicosanoids and prostaglandi...
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Article
The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells
Loss of the tumor suppressor gene NF1 in neurofibromatosis type 1 (NF1) contributes to the development of a variety of tumors, including malignant peripheral nerve sheath tumors (MPNST) and benign neurofibromas. ...
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Article
Open AccessSulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients
Malignant peripheral nerve sheath tumors (MPNSTs) are neoplasms leading to death in most cases. Patients with Neurofibromatosis type 1 have an increased risk of develo** this malignancy. The metabolites of t...
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Article
Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids
Neurofibromatosis type 1 (NF1) is a common genetic disorder of the nervous system resulting in neurofibromas and malignant peripheral nerve sheath tumors (MPNST). In this study, we report the modulation of mur...
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Article
First evaluation of the European hESCreg
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Article
Open AccessHistone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro. Decreased expression of histone deac...
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Article
Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model
Plexiform neurofibromas (PNF), one of the major features of neurofibromatosis type 1 (NF1), are characterized by complex cellular composition and mostly slow but variable growth patterns. In this study, we exa...
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Article
Isolation and characterization of fenamiphos degrading bacteria
The biological factors responsible for the microbial breakdown of the organophosphorus nematicide fenamiphos were investigated. Microorganisms responsible for the enhanced degradation of fenamiphos were isolat...
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Article
Open AccessIdentification of diagnostic serum protein profiles of glioblastoma patients
Diagnosis of a glioblastoma (GBM) is triggered by the onset of symptoms and is based on cerebral imaging and histological examination. Serum-based biomarkers may support detection of GBM. Here, we explored ser...
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Chapter
Status and Impact of Research on Human Pluripotent Stem Cells: Cell Lines and Their Use in Published Research
Research on human pluripotent stem cells is rapidly progressing. In the present chapter the current state of research on human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) is ...
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Article
Open AccessScope and Impact of International Research in Human Pluripotent Stem Cells
In a recent study published in this journal it was claimed that the rate of publications from US-based authors in the human embryonic stem cell (hESC) research field was slowing or even declining from 2008 to ...
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Article
Open AccessSerum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors
Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by the development of benign nerve-sheath tumors, which transform to malignant peripheral nerve-sheath tumors (MPNST) in about 8 to 1...
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Article
Open AccessCELDA - an ontology for the comprehensive representation of cells in complex systems
The need for detailed description and modeling of cells drives the continuous generation of large and diverse datasets. Unfortunately, there exists no systematic and comprehensive way to organize these dataset...
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Article
Open AccessImpact of heart failure on the behavior of human neonatal stem cells in vitro
Clinical cardiac cell therapy using autologous somatic stem cells is restricted by age and disease-associated impairment of stem cell function. Juvenile cells possibly represent a more potent alternative, but ...
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Article
Open AccessUsing ontologies to study cell transitions
Understanding, modelling and influencing the transition between different states of cells, be it reprogramming of somatic cells to pluripotency or trans-differentiation between cells, is a hot topic in current...
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Article
Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs)
Neurofibromatosis type 1 (NF1) is an inherited genetic disease affecting 1 in 3,500 individuals. A prominent feature of NF1 is the formation of benign tumours of the peripheral nerve sheath (neurofibromas). Ho...
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Article
Open AccessComparative computational analysis of pluripotency in human and mouse stem cells
Pluripotent cells can be subdivided into two distinct states, the naïve and the primed state, the latter being further advanced on the path of differentiation. There are substantial differences in the regulati...
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Article
Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson’s Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids
Adult human adipose-derived mesenchymal stem cells (MSC) have been reported to induce neuroprotective effects in models for Parkinson´s disease (PD). However, these effects strongly depend on the most optimal ...
