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  1. No Access

    Article

    Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

    MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major chal...

    Sung Wook Chi, Julie B. Zang, Aldo Mele, Robert B. Darnell in Nature (2009)

  2. No Access

    Article

    HITS-CLIP yields genome-wide insights into brain alternative RNA processing

    Protein–RNA interactions have critical roles in all aspects of gene expression. However, applying biochemical methods to understand such interactions in living tissues has been challenging. Here we develop a g...

    Donny D. Licatalosi, Aldo Mele, John J. Fak, Jernej Ule, Melis Kayikci… in Nature (2008)

  3. No Access

    Article

    An RNA map predicting Nova-dependent splicing regulation

    Nova proteins are neuron-specific alternative splicing factors. We have combined bioinformatics, biochemistry and genetics to derive an RNA map describing the rules by which Nova proteins regulate alternative ...

    Jernej Ule, Giovanni Stefani, Aldo Mele, Matteo Ruggiu, Xuning Wang, Bahar Taneri… in Nature (2006)