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Article
SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells
Recurrent mutations in the splicing factor SRSF2 are associated with poor clinical outcomes in myelodysplastic syndromes (MDS). Their high frequency suggests these mutations drive oncogenesis, yet the molecular e...
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Chapter and Conference Paper
Does an Electron Pair Diffract as a Whole?
The correlated behavior of the electrons in atoms, molecules and solids has been, and still is, a crucial issue for the quantum mechanics. Lately, experiments in which either a photon or an electron ionizes a ...
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Article
Open AccesspiRNA involvement in genome stability and human cancer
PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. They form complexes with several members of the PIWI clade of Argonaute prote...
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Chapter
Photoemission Spectroscopy: Fundamental Aspects
Over the past five decades, photoemission has become one of the most popular spectroscopies for investigating matter in its various aggregation states. It finds its application in fields ranging from solid sta...
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Article
A 'pivotal' new rule for microRNA-mRNA interactions
Finding biologically relevant targets is a prerequisite for understanding the function of any trans regulator of gene expression, but this can be particularly challenging with microRNAs (miRNAs). A study in this ...
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Article
Small non-coding RNAs in animal development
The functional roles of small non-coding RNAs in vertebrates are beginning to be elucidated thanks to specific gene-deletion approaches.
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Article
An RNA map predicting Nova-dependent splicing regulation
Nova proteins are neuron-specific alternative splicing factors. We have combined bioinformatics, biochemistry and genetics to derive an RNA map describing the rules by which Nova proteins regulate alternative ...
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Article
Introduction
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Chapter
Correlation Experiments with Secondary Electrons
In the final state of an electron induced ionisation event there are at least three unbound charged particles interacting via long range Coulomb forces. Due to the nature of the Coulomb field, they are never i...
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Chapter
Correlation Effects in (e,2e) Processes
Electron impact scattering processes have always played a relevant role in the field of atomic collisions and in recent years the application of coincidence techniques has allowed several crucial tests both fo...
