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  1. No Access

    Article

    Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

    RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2′-O-methylation (...

    Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele… in Nature Genetics (2019)

  2. Article

    Erratum: Map** Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

    Nat. Protoc. 9, 263–293 (2014); published online 9 January 2014; corrected after print 24 February 2016 In the version of this article initially published, units were incorrectly reported in Step 2 of the Proc...

    Michael J Moore, Chaolin Zhang, Emily Conn Gantman, Aldo Mele… in Nature Protocols (2016)

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  3. No Access

    Article

    Map** Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

    The identification of sites where RNA-binding proteins (RNABPs) interact with target RNAs opens the door to understanding the vast complexity of RNA regulation. UV cross-linking and immunoprecipitation (CLIP) ...

    Michael J Moore, Chaolin Zhang, Emily Conn Gantman, Aldo Mele… in Nature Protocols (2014)

  4. No Access

    Article

    Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

    MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major chal...

    Sung Wook Chi, Julie B. Zang, Aldo Mele, Robert B. Darnell in Nature (2009)

  5. No Access

    Article

    HITS-CLIP yields genome-wide insights into brain alternative RNA processing

    Protein–RNA interactions have critical roles in all aspects of gene expression. However, applying biochemical methods to understand such interactions in living tissues has been challenging. Here we develop a g...

    Donny D. Licatalosi, Aldo Mele, John J. Fak, Jernej Ule, Melis Kayikci… in Nature (2008)

  6. No Access

    Article

    An RNA map predicting Nova-dependent splicing regulation

    Nova proteins are neuron-specific alternative splicing factors. We have combined bioinformatics, biochemistry and genetics to derive an RNA map describing the rules by which Nova proteins regulate alternative ...

    Jernej Ule, Giovanni Stefani, Aldo Mele, Matteo Ruggiu, Xuning Wang, Bahar Taneri… in Nature (2006)