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Article
Open AccessBortezomib-induced neuropathy is in part mediated by the sensitization of TRPV1 channels
TRPV1 is an ion channel that transduces noxious heat and chemical stimuli and is expressed in small fiber primary sensory neurons that represent almost half of skin nerve terminals. Tissue injury and inflammat...
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Article
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, ...
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Article
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain1–4. Mental influence on perception is largely assumed to occur locally within ...
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Article
Combining Human and Rodent Genetics to Identify New Analgesics
Most attempts at rational development of new analgesics have failed, in part because chronic pain involves multiple processes that remain poorly understood. To improve translational success, one strategy is to...
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Article
Decreased alertness due to sleep loss increases pain sensitivity in mice
In mice, sleep loss increases sensitivity to painful stimuli. Restoration of normal sleep or acute treatment with wake-promoting agents can normalize pain sensitivities.
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Article
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase
Inhibition of T cell–derived leukocyte elastase by neuronal SerpinA3N or the drug Sivelestat reduces neuropathic pain.
