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Article
Open AccessLocal delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth
The Accum® platform was initially designed to accumulate biomedicines in target cells by inducing endosomal-to-cytosol escape. Interestingly however, the use of unconjugated Accum® was observed to trigger cell de...
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Article
Open AccessNociceptor neurons affect cancer immunosurveillance
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems1–5. Whether the neo-innervation of tumours by pain-initiating sensory neurons affects cancer immun...
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Article
Open AccessAnatomical differences in nociceptor neurons sensitivity
Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These gan...
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Protocol
Analysis of Airway Vagal Neurons
Internal organs, including the airway, are innervated by neurons of the autonomic and sensory nervous systems. The airway-innervating sensory neurons primarily originate from the vagus nerve, whose cell bodies...
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Article
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation1,2, but whether nociceptors also interact with...
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Article
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, ...
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Article
Open AccessNeuronal Circuits Modulate Antigen Flow Through Lymph Nodes
When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, b...
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Article
Open AccessActivation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat
Kinins are mediators of pain and inflammation. Their role in thermoregulation is, however, unknown despite the fact the B1 receptor (B1R) was found implicated in lipopolysaccharide (LPS)-induced fever. The aim...
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Article
Open AccessActivation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia
The kinin B1 receptor (B1R) is upregulated by pro-inflammatory cytokines and oxydative stress, which are enhanced by transient receptor potential vanilloid subtype 1 (TRPV1) activation. To examine the link betwee...
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Article
Open AccessKey role for spinal dorsal horn microglial kinin B1receptor in early diabetic pain neuropathy
The pro-nociceptive kinin B1 receptor (B1R) is upregulated on sensory C-fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat. This study aims at defining the role of microglial...
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Article
Open AccessCellular localization of kinin B1 receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [Nα-Bodipy]-des-Arg9-bradykinin
The kinin B1 receptor (B1R) is upregulated by pro-inflammatory cytokines, bacterial endotoxins and hyperglycaemia-induced oxidative stress. In animal models of diabetes, it contributes to pain polyneuropathy. Thi...
