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  1. No Access

    Article

    Neuromodulation Treatments for Mild Traumatic Brain Injury and Post-concussive Symptoms

    Mild traumatic brain injury (mTBI) can result in prolonged post-concussive symptoms (e.g., depression, headaches, cognitive impairment) that are debilitating and difficult to treat. This article reviews recent...

    Adriano Mollica, Rachel Greben, Chika Oriuwa… in Current Neurology and Neuroscience Reports (2022)

  2. No Access

    Article

    Structure-based virtual screening, molecular docking and dynamics studies of natural product and classical inhibitors against human dihydrofolate reductase

    Folate antagonists are classified as important and valuable therapeutic agents against infection, neoplastic, and inflammatory diseases. Dihydrofolate reductase (DHFR) is a biological target of two well-define...

    Elnaz Hosseininezhadian Koushki… in Network Modeling Analysis in Health Inform… (2020)

  3. No Access

    Article

    Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence

    Multiple sclerosis (MS) is a devastating chronic autoimmune demyelinating disease of the central nervous system (CNS), thought to affect more than 2.5 million people worldwide. Regulation of the sleep-wake cyc...

    Mahshid Yeganeh Salehpour, Adriano Mollica, Saeideh Momtaz… in Clinical Drug Investigation (2019)

  4. Article

    Open Access

    On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity

    Here, we report the chemical synthesis of two DPDPE analogues 7a (NOVA1) and 7b (NOVA2). This entailed the solid-phase synthesis of two enkephalin precursor chains followed by a CuI-catalyzed azide-alkyne cycload...

    Azzurra Stefanucci, Wei Lei, Stefano Pieretti, Ettore Novellino… in Scientific Reports (2019)

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  5. No Access

    Article

    Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators

    The discovery of novel modulators of the cannabinoid system is a current topic in medicinal chemistry. In this paper, we report nine novel carboxamides designed as hybrids of Fubinaca family compounds and Rimo...

    Azzurra Stefanucci, Giorgia Macedonio, Szabolcs Dvorácskó, Csaba Tömböly… in Amino Acids (2018)

  6. No Access

    Article

    In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells

    Juncunol is a phenanthrene isolated from the halophyte species Juncus acutus, with selective cytotoxic activity towards human hepatocarcinoma (HepG2) cells. However, its mechanism of action is unknown.

    Maria João Rodrigues, Catarina Vizetto-Duarte… in Pharmacological Reports (2018)

  7. No Access

    Article

    Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat

    The endocannabinoid (eCB) system is strongly involved in the regulation of anxiety and feeding behavior. RVD-hemopressin(α) [RVD-hp(α)], a N-terminally extended form of hemopressin, is a negative allosteric mo...

    Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante… in Pharmacological Reports (2018)

  8. No Access

    Article

    Anorexigenic effects induced by RVD-hemopressin(α) administration

    Hemopressin, VD-hemopressin(α) and RVD-hemopressin(α) are hemoglobin α chain derived-peptides which have been found in mouse brain, and where they modulate cannabinoid (CB) receptor function. The nonapeptide h...

    Claudio Ferrante, Lucia Recinella, Sheila Leone… in Pharmacological Reports (2017)

  9. No Access

    Article

    Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats

    The endocannabinoid (eCB) system plays an important role in regulating emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as anxiety and depression. Hemopressin, a hemo...

    Sheila Leone, Lucia Recinella, Annalisa Chiavaroli… in Pharmacological Reports (2017)

  10. No Access

    Article

    The Positive Regulation of eNOS Signaling by PPAR Agonists in Cardiovascular Diseases

    Increasing evidence shows that activation of peroxisome proliferator-activated receptors (PPARs) plays an essential role in the regulation of vascular endothelial function through a range of mechanisms, includ...

    Cristina Maccallini, Adriano Mollica… in American Journal of Cardiovascular Drugs (2017)

  11. No Access

    Article

    CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

    Parkinson’s disease (PD) is a neurodegenerative disorder associated primarily with loss of dopamine (DA) neurons in the nigrostriatal system. With the aim of increasing the bioavailability of l-dopa (LD) after or...

    Francesco Pinnen, Ivana Cacciatore, Catia Cornacchia, Adriano Mollica… in Amino Acids (2012)

  12. No Access

    Article

    New potent biphalin analogues containing p-fluoro-l-phenylalanine at the 4,4′ positions and non-hydrazine linkers

    We report the synthesis and the biological evaluation of two new analogues of the potent dimeric opioid peptide biphalin. The performed modification is based on the replacement of two key structural elements o...

    Adriano Mollica, Francesco Pinnen, Federica Feliciani, Azzurra Stefanucci… in Amino Acids (2011)

  13. No Access

    Chapter and Conference Paper

    Development of μ Opioid Receptor Selective 4-Anilinidopiperidine Analogs

    Yeon Sun Lee, Joel Nyberg, Sharif Moye… in Understanding Biology Using Peptides (2006)