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Article
Empagliflozin protective effects against cisplatin-induced acute nephrotoxicity by interfering with oxidative stress and inflammation in Wistar rats
Cisplatin (Cis) is a platinum-based antineoplastic drug used in various types of cancers. This drug can induce nephrotoxicity as a cause of acute kidney injury (AKI) by inducing oxidative stress and inflammati...
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Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes
Diabetes mellitus is a chronic metabolic disease with a high global incidence that can lead to serious and life-threatening conditions. Diabetes mellitus and its related complications are associated with sever...
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Article
Open AccessProtective Effects of Plant-Derived Compounds Against Traumatic Brain Injury
Inflammation in the nervous system is one of the key features of many neurodegenerative diseases. It is increasingly being identified as a critical pathophysiological primitive mechanism associated with chroni...
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Article
Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a crucial role in many diseases such as cholestasis liver diseases...
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Article
Superoxide dismutase: a key target for the neuroprotective effects of curcumin
Over the past few years, the prevalence of neurodegenerative diseases (NDD) has increased dramatically. The community health system is burdened by the high healthcare costs associated with NDD. Superoxide dism...
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Article
Sodium Glucose Transporter-2 Inhibitors (SGLT2Is)-TLRs Axis Modulates Diabetes
Diabetes affects millions of people worldwide and is mainly associated with impaired insulin function. To date, various oral anti-diabetic drugs have been developed, of which, the sodium glucose transporter-2 ...
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Article
Impact of curcumin on p38 MAPK: therapeutic implications
Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number o...
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Article
Licofelone Attenuates Acetic Acid-Induced Colitis in Rats Through Suppression of the Inflammatory Mediators
Licofelone is a dual Cyclooxygenase 1,2 (COX1,2)/5-lipoxygenase) 5-LOX (inhibitor with analgesic and anti-inflammatory effects with possible functions on inflammatory bowel disease (IBD), which is a chronic re...
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Therapeutic Potentials and Candidates for COVID-19
The current coronavirus disease 2019 (COVID-19) outbreak spread rapidly worldwide. Yet, there is no identifiable antiviral treatment, so an effective drug is urgently needed. Preventive strategies and oxygen t...
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Article
The Hydro-alcoholic Extract of Achillea wilhelmsii C. Koch Ameliorates Acetic Acid-induced Ulcerative Colitis through TLR-4
Achillea wilhelmsii contains several anti-inflammatory and antioxidant phytochemicals, proposing protecting effect on inflammatory responses in autoimmune diseases such as inflammatory bowel diseases. However, it...
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Article
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial...
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Chapter
Statins: Beneficial Effects in Treatment of COVID-19
The recent viral disease COVID-19 has attracted much attention. The disease is caused by SARS-CoV-19 virus which has different variants and mutations. The mortality rate of SARS-CoV-19 is high and efforts to e...
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Article
Ameliorative effects of standardized extract of Tamarix stricta Boiss. on acetic acid-induced colitis via modulating nitrergic pathways
Inflammatory bowel disease (IBD) is a chronic recurrent disease with no certain treatment. Tamarisk is a medicinal plant mentioned in Persian medicine as an effective treatment for gastrointestinal bleeding. C...
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Chapter
Biology of SARS-CoV-2 Coronavirus; Origin, Structure, and Variants
Emerging viral infections have been known as a significant threat of recent years. Coronavirus-2 (SARS-CoV-2) was initially recognized in China and infected a large population through inhalation of droplets. M...
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Article
Cinnamaldehyde targets TLR-4 and inflammatory mediators in acetic-acid induced ulcerative colitis model
Cinnamon and its bioactive ingredients such as cinnamaldehyde (CA), with broad pharmacological profiles, are important parts of daily diet in many cultures. Moreover, there are plenty motivating patents on eff...
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Article
Current overview of opioids in progression of inflammatory bowel disease; pharmacological and clinical considerations
Inflammatory bowel diseases (IBD) belong to a subgroup of persistent, long-term, progressive, and relapsing inflammatory conditions. IBD may spontaneously develop in the colon, resulting in tumor lesions in in...
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Article
Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease
Chronic inflammation of the gastrointestinal system is mediated by both the immune system activity and homeostasis, mainly through releasing of various cytokines and chemokines, as well as the transmigration o...
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Chapter
Dietary Fiber and Aging
Currently, healthy aging is a major public concern. In between, nutritional interventions and dietary patterns are supposed to play crucial roles in regulation/delaying the aging process. High intake of dietar...
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Chapter
Hepatobiliary Tumors: Immunopathology and Immunotherapy
Liver neoplasms are a kind of digestive cancers, by which hepatocellular carcinoma is one of the main pathological types of liver cancer that are associated with chronic viral hepatitis and cirrhosis. Conventi...
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Article
Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review
Irritable bowel syndrome (IBS) is a well diagnosed disease, thoroughly attributed to series of symptoms criteria that embrace a broad range of abdominal complainers. Such criteria help to diagnosis the disease...
