![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Concerted evolution rapidly eliminates sequence variation in rDNA coding regions but not in intergenic spacers in Nicotiana tabacum allotetraploid
Nicotiana tabacum (tobacco) is a natural allotetraploid that formed from two diploid progenitors (N. sylvestris—S-genome, N. tomentosiformis—T-genome) within past 0.2 million years. Previ...
-
Article
Open AccessDefective removal of ribonucleotides from DNA promotes systemic lupus erythematosus
-
Article
Open AccessNuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma
Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU). Nuclear expression of TS in human tissue in vivo has not been char...
-
Article
A trial of four anti-depressant drugs
A trial of four anti-depressant drugs is described. The patients were assessed at the end of the four weeks without the doctor knowing which drug the patient had been receiving.