27 Result(s)
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Article
Modulators of the Nrf2 Signaling Pathway Enhance the Cytotoxic Effect of Standard Chemotherapeutic Drugs on Organoids of Metastatic Colorectal Cancer
The activity of known modulators of the Nrf2 signaling pathway (bardoxolone and brusatol) was studied on cultures of tumor organoids of metastatic colorectal cancer previously obtained from three patients. The...
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Article
Metabolic Reprogramming of Trophoblast Cells in Response to Hypoxia
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells....
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Article
Oxyquinoline-Dependent Changes in Claudin-Encoding Genes Contribute to Impairment of the Barrier Function of the Trophoblast Monolayer
Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia...
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Serum Metabolic Profiles of Pregnant Women with Burdened Obstetrical History
The content of low-molecular-weight components in blood serum was studied by tandem mass-spectrometry in pregnant women. Serum metabolic profiles of patients with a grave obstetrical history were detected. The...
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Article
Changes in Parameters of Laser-Induced Potentials After Transcutaneous Electroneurostimulation
Changes in nerve conduction after 10-min electroneurostimulation of the posterior surface of the neck were studied. Changes in the parameters of laser-induced potentials obtained during stimulation of C7 derma...
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Article
Association of SLC6A4 Gene 5-HTTLPR Polymorphism with Parameters of Simple and Complex Reaction Times and Critical Flicker Frequency Threshold in Athletes during Exhaustive Exercise
The incidence of SLC6A4 gene 5HTTLPR polymorphism alleles was evaluated in 223 male athletes engaged in endurance sports, the results were compared with those in 177 male nonathletes. Association between 5-HTTLPR...
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Article
Relationship between Lactate Concentrations in Active Muscle Sweat and Whole Blood
Lactate (lactic acid) concentrations in sweat and venous and capillary blood of athletes were measured before and after exercise of the maximum aerobic power. Correlations between the increment of blood and sw...
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Article
Modulation of α-Rhythm and Autonomic Status of Human by Color Photostimulation
The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: α-rhythm amplitude increases ...
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Article
Short Highly Intense Exercise Causes Changes in Salivary Concentrations of Hydrocortisone and Secretory IgA
The dynamics of salivary hydrocortisone during exercise depends on the professional status of the athlete. Hydrocortisone concentrations increase and those of secretory IgA decrease significantly during short-...
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Article
Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental wo...
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Article
New Aspects of the Influence of Quadriceps Femoris Muscle Stimulation Course on Functional Capabilities of the Organism
We studied the effect of a course of electrical stimulation of the quadriceps femoris muscle with submaximal contraction under biofeedback conditions on functional capabilities of the organism. In addition to ...
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Article
Expression of Early Immune Response Genes during Physical Exercise
Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They ...
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Article
Cross Effect of Electrostimulation of Quadriceps Femoris Muscle during Maximum Voluntary Contraction under Conditions of Biofeedback
We describe cross effect of enhancement of muscular power and electrical activity during electrical stimulation. Due to the use of electrostimulation method with biological feedback and effort visualization fo...
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Article
Prediction of Epitopes in Closely Related Proteins Using a New Algorithm
Latrophilin 1 (presynaptic receptor) binds α-latrotoxin from black widow spider venom and regulates neurotransmitter release from nerve endings. The study of the mechanism of action of this receptor is impeded...
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Article
Application of Mid-Infrared Molecular Spectroscopy for Assessment of Biochemical Parameters of Blood Serum
The method of mid-infrared molecular spectroscopy allows precise measuring of the concentrations of a large number of biological molecules in a minimal sample volume. Method of projections on latent structures...
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Article
Peculiarities of Brain Information Processing in Persons with Different Serotonin Transporter Gene Variants
Association of brain processes presumably underlying aggression with serotonin transporter gene polymorphism in men was studied. Carriers of more active gene variant are characterized by higher aggression inde...
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Article
Effect of a Six-Hour Marathon Ultra-Race on the Levels of IL-6, LIF, and SCF
The effects of 6-h marathon ultra-race (long aerobic work below the lactate threshold level) on the levels of IL-6, leukemia inhibiting factor (LIF), and stem cell growth factor (SCF) were studied. The athlete...
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Article
Assessment of Biochemical Characteristics of the Saliva Using Fourier Transform Mid-Infrared Spectroscopy
We developed a method of rapid assay for biochemical properties of the saliva based on attenuated total reflection infrared spectroscopy. This method allows evaluating saliva composition within 5 min without s...
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Article
Studying the Copy Number of Ribosomal Protein L7/L12
Studying the copy number of ribosomal protein L7/L12 was performed using monoclonal antibody 3G9 to the linear epitope on the C-terminal domain of this protein from Escherichia coli. Immunohistochemical study sho...
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Article
Gender Effects on Association of Serotonin Transporter Gene Polymorphism with Symptoms of Central Fatigue
In order to test the “serotonin” hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task ...
