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Article
Open AccessEbstein’s anomaly may be caused by mutations in the sarcomere protein gene MYH7
Ebstein’s anomaly is a rare congenital heart malformation characterised by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. Associated abnormalities of left v...
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Article
Open AccessCardiovascular development: towards biomedical applicability
The heart of higher vertebrates is a structurally complicated multi-chambered pump that contracts synchronously. For its proper function a number of distinct integrated components have to be generated, includi...
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Article
Sarcoglycanopathies in Dutch patients with autosomal recessive limb girdle muscular dystrophy
Within a group of 76 sporadic/autosomal recessive limb girdle muscular dystrophy (LGMD) patients we tried to identify those with LGMD type 2C-E. Muscle biopsy specimens of 40 index patients, who had 22 affect...
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Article
Basic strategies for valid cytometry using image analysis
The present review provides a starting point for setting up an image analysis system for quantitative densitometry and absorbance or fluorescence measurements in cell preparations, tissue sections or gels. Gui...
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Article
Presence of cardiac α-myosin correlates with histochemical myosin Ca2+ ATPase activity in rabbit masseter muscle
A combined enzyme-histochemical (ATPase reactivity) and immunohistochemical study has been performed on sections of rabbit masseter muscle. The majority of the fibres previously designated as type IIC and/or t...
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Article
Demonstration of ‘cardiac-specific’ myosin heavy chain in masticatory muscles of human and rabbit
Human and rabbit masticatory muscles were analyzed immuno-and enzyme-histochemically using antibodies specific to ‘cardiac’ α, slow and fast myosin heavy chain isoforms. In human masseter, temporalis, and late...
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Article
Expression patterns of mRNAs for α-fetoprotein and albumin in the develo** rat: the ontogenesis of hepatocyte heterogeneity
In develo** and normal adult rat liver the expression patterns of the mRNAs for α-fetoprotein (AFP) and albumin (ALB) were analysed byin situ hybridization using specific35S-labelled complementary DNA probes. I...
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Article
Expression patterns of mRNAs for ammoniametabolizing enzymes in the develo** rat: the ontogenesis of hepatocyte heterogeneity
The expression patterns of the mRNAs for the ammonia-metabolizing enzymes carbamoylphosphate synthetase (CPS), glutamine synthetase (GS) and glutamate dehydrogenase (GDH) were studied in develo** pre- and ne...
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Article
Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts
Isolated rat hepatocytes were transplanted into the interscapular and both anterior lateral fat pads of hepatectomized syngeneic rats. At various time points following transplantation, the fat pads were remove...
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Article
Noradrenergic innervation of develo** rat and spiny mouse liver
The development of noradrenergic innervation of rat liver was studied with a polyclonal antiserum against noradrenaline. Nerves are first seen in the larger portal vessels at day 1 after birth and reach their ...
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Article
Isomyosin expression patterns in tubular stages of chicken heart development: a 3-D immunohistochemical analysis
The 3-D distribution of atrial and ventricular isomyosins is analysed in tubular chicken hearts (stage 12+ to 17 (H/H)) using antibodies specific for adult chicken atrial and ventricular myosin heavy chains, r...
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Article
The local expression of adult chicken heart myosins during development
The development of the ventricular conducting tissue of the embryonic chicken heart has been studied using a previous finding that morphologically recognizable atrial conducting tissue coexpresses the atrial a...
