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Article
Open AccessNitrofurantoin for the treatment of uncomplicated urinary tract infection in female patients: the impact of dosing regimen, age, and renal function on drug exposure
The aim of this study is to determine nitrofurantoin exposure in female patients with different age and renal function with complaints of an uncomplicated UTI. Also the nitrofurantoin exposure in relation to t...
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Article
Open AccessPrescription opioids among older adults: ten years of data across five countries
Opioid use has increased globally in the recent decade. Although pain remains a significant problem among older adults, susceptibility to opioid-related harms highlights the importance of careful opioid therap...
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Article
Open AccessThe effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial
Critically ill patients undergo extensive physiological alterations that will have impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet the pharmacodynamic targets of bet...
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Article
Open AccessDynamics of colistin and tobramycin resistance among Enterobacter cloacae during prolonged use of selective decontamination of the digestive tract
A high prevalence of colistin resistance among E. cloacae isolates in two intensive care units (ICU) (of 16 and 6 beds) using selective digestive decontamination (SDD) since 1990 instigated a retrospective and pr...
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Article
BvPRR7 is a cold responsive gene with a clock function in beet
The life cycle of flowering plants is partially defined by environmental cues like day length and temperature. In the model plant Arabidopsis thaliana and temperate cereals, such as barley (Hordeum vulgare) and w...
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Article
Open AccessIn vitro evaluation of the performance of Granada selective enrichment broth for the detection of group B streptococcal colonization
A broth for the screening of group B streptococcal (GBS) carriage during pregnancy is about to be introduced. Simulating conditions in everyday practice, we have compared the sensitivity of this Granada tube b...
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New Views on the Origin of Primate Social Organization
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Article
Progressive Hautveränderung bei einem Säugling
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Article
Analysis of von Willebrand factor in platelets of patients with various forms of von Willebrand disease: Is there a clinical relevance?
Besides the investigation of coagulation factor VIII:c and von Willebrand factor in plasma, vWF antigen and vWF collagen-binding activity in platelets of 24 patients with various forms of von Willebrand disea...
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Article
Cystic fibrosis: a cause of reduced birth weight?
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Article
The transformation booster sequence from Petunia hybrida is a retrotransposon derivative that binds to the nuclear scaffold
The transformation booster sequence (TBS) from Petunia hybrida enhances transformation frequencies in P. hybrida, Nicotiana tabacum and Zea mays. TBS also stimulates homologous inter- and intramolecular recombina...
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Article
Prediction of First Phase Formation at Au-METAL Interfaces Using the Effective Heat of Formation Model
The effective heat of formation model enables heats of formation to be calculated as a function of concentration. By choosing the effective concentration at the growth interface to be that of the liquidus mini...
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Article
Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease
A female patient suffering from a bronchial neuroendocrine tumor with unilateral leftsided carcinoid heart disease is reported. Repeated x-ray films of the chest showed a slowly growing lung tumor in the left ...
