27 Result(s)
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Article
Complex segregation analysis reveals a multigene model for lung cancer
Lung cancer risk is largely attributed to tobacco exposure, but genetic predisposition also plays an etiologic role. Several studies have investigated the involvement of genetic predisposition in lung cancer a...
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A new transgene reporter for in vivo magnetic resonance imaging
We report a new platform technology for visualizing transgene expression in living subjects using magnetic resonance imaging (MRI). Using a vector, we introduced an MRI reporter, a metalloprotein from the ferr...
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Parent–child pair design for detecting gene–environment interactions in complex diseases
It is becoming clear that the etiology of complex diseases involves not only genetic and environmental factors but also gene–environment (GE) interactions. Therefore, it is important to take account of all the...
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Article
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
Aberrant wound-healing responses to injury have been implicated in the development of pulmonary fibrosis, but the mediators directing these pathologic responses have yet to be fully identified. We show that ly...
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Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing
Retinitis pigmentosa (RP) is the most common and highly heterogeneous form of hereditary retinal degeneration. This study was to identify mutations in the 60 genes that were known to be associated with RP in 1...
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Uncultured bone marrow mononuclear cells delay the dedifferentiation of unexpanded chondrocytes in pellet culture
Uncultured bone marrow mononuclear cells (BMMC) were recently used to successfully repair damaged cartilage. However, the effect of BMMCs on the proliferation and differentiation of chondrocytes that are criti...
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Assessment of Itch and Pain in Animal Models and Human Subjects
For the past century, scientists have developed a variety of methods to evaluate itch and pain in both animal models and human subjects to throw light on some of the most important pathways mediating these unp...
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Article
XCI-esca** gene KDM5C contributes to ovarian development via downregulating miR-320a
Mechanisms underlying female gonadal dysgenesis remain unclarified and relatively unstudied. Whether X-chromosome inactivation (XCI)-esca** genes and microRNAs (miRNAs) contribute to this condition is curren...
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Pharmacokinetics of Bispecific Antibody
This article provides a brief overview of bispecific antibody (BsAb) mechanisms of action, structures, and pharmacokinetic (PK) properties, including absorption, distribution, and elimination. Recent trend in ...
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Article
L1CAM drives oncogenicity in esophageal squamous cell carcinoma by stimulation of ezrin transcription
L1 cell adhesion molecule (L1CAM) is highly expressed in various types of human cancers, displaying yet unknown molecular mechanisms underlying their oncogenic potential. Here, we found that L1CAM expression w...
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β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice
Despite substantial progress being made in understanding the mechanisms contributing to the pathogenesis of renal fibrosis, there are only a few therapies available to treat or prevent renal fibrosis in clinic...
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Chapter
Progress of Genomics in Cardiac Conduction and Rhythm Disorders
Genes and genetic loci linked thus far to cardiac electrical function and arrhythmia have been primarily uncovered through numerous studies. The contribution of epigenetics to heart rhythm disorders has also r...
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Article
Open AccessMASAN: a novel staging system for prognosis of patients with oesophageal squamous cell carcinoma
Oesophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers worldwide. Treatment of ESCC is in progress through accurate staging and risk assessment of patients. The emergence of potential ...
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Comment on “Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis”
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What We Can Learn from Current Inflammatory Bowel Disease (IBD) Biological Therapy—Dose Regimen and Others
Inflammatory bowel disease (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC), is an unmet need as indicated by less than ideal remission rates with current treatments. Understanding the clinical ...
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Open AccessTargeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
Traumatic brain injury (TBI) is a major cause of CNS neurodegeneration and has no disease-altering therapies. It is commonly associated with a specific type of biomechanical disruption of the axon called traum...
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Attenuated regenerative properties in human periodontal ligament–derived stem cells of older donor ages with shorter telomere length and lower SSEA4 expression
Periodontal ligament (PDL) stem cell properties are critical in the periodontal tissue regeneration for periodontitis. Previously, we have demonstrated that cigarette smoking attenuates PDL-derived stem cell (...
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Open AccessAneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation
Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy the spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing an...
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Article
CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemia
The NF-κB signaling pathway is an important downstream pathway of oncogenic Notch1 in T cell acute lymphoblastic leukemia (T-ALL) cells. However, the molecular mechanisms underlying the cascade activation of N...
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Open AccessA new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire
Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies, so it is still urgent to find and prepare neutralization antibodies for COVID-19 preve...
