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Article
Open AccessA “Prime and Expand” strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy
Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15, and IL-18, has shown promise for treating hematologic maligna...
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Article
Extropy Properties of Ranked Set Sample for Cambanis Type Bivariate Distributions
In this paper, the extropy of concomitants of order statistics and its properties when samples from Cambanis Type Bivariate Distributions is considered. By deriving the expression for extropy of concomitants o...
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Article
Altered mental status is an independent predictor of mortality in hospitalized COVID-19 patients
Limited data exists on the outcomes of COVID-19 patients presenting with altered mental status (AMS). Hence, we studied the characteristics and outcomes of hospitalized COVID-19 patients who presented with AMS...
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Article
Open AccessAn analytical model of population level chronic conditions and COVID-19 related hospitalization in the United States
The surge in the COVID-19 related hospitalization has been straining the US health system. COVID-19 patients with underlying chronic conditions have a disproportionately higher risk of hospitalization and inte...
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Chapter and Conference Paper
Exploring the Application of Data Envelopment Analysis in the Evaluation of Public Transport Organizations
The work provides details on a study on performing a comparative analysis of productivity and efficiency of selected public transport organizations in India. The data envelopment analysis (DEA) method was used in...
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Article
Open AccessPerformance Optimization of Public Transport Using Integrated AHP–GP Methodology
The State Road Transport Undertakings (SRTUs) are the economic providers of mass transport in India. The institutional constraints imposed on the SRTUs result in low productivity and inefficiency. In this fier...
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Article
Effect of Soil Parameters on Resilient Modulus Using Cyclic Tri-Axial Tests on Lateritic Subgrade Soils from Dakshina Kannada, India
Resilient modulus (Mr) of a soil is used as a basic input in the analysis of sub-grade and sub-base in the mechanistic empirical design approaches. The present work focuses on evolving a cost effective approach f...
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Article
Open AccessComparison of several sequence-based association methods in pedigrees
Genome-wide association studies are very powerful in determining the genetic variants affecting complex diseases. Most of the available methods are very useful in detecting association between common variants ...
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Article
Open AccessA gene-based approach for testing association of rare alleles
Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we a...
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Article
Open AccessA Monte Carlo test of linkage disequilibrium for single nucleotide polymorphisms
Genetic association studies, especially genome-wide studies, make use of linkage disequilibrium(LD) information between single nucleotide polymorphisms (SNPs). LD is also used for studying genome structure and...
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Article
Effect of aggregate gradations on properties of porous friction course mixes
This paper presents the study on effect of aggregate gradation on the mix design and performance properties of porous friction course (PFC) mixes. Six aggregate gradations were tested with due consideration to...
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Article
Open AccessSimultaneous analysis of all single-nucleotide polymorphisms in genome-wide association study of rheumatoid arthritis
The availability of very large number of markers by modern technology makes genome-wide association studies very popular. The usual approach is to test single-nucleotide polymorphisms (SNPs) one at a time for ...
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Article
Open AccessFamily-based genome-wide association study for simulated data of Framingham Heart Study
Genome-wide association studies (GWAS) have quickly become the norm in dissecting the genetic basis of complex diseases. Family-based association approaches have the advantages of being robust to possible hidd...
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Article
Effect of Soil Parameters on Dynamic Cone Penetration Indices of Laterite Sub-grade Soils from India
The focus of this study was on correlating the effect of grain-size, maximum dry-density (MDD), field moisture content, and the void ratios on penetration measured using the dynamic cone penetrometer (DCP) for...
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Article
Open AccessA new measure of population structure using multiple single nucleotide polymorphisms and its relationship with FST
Large-scale genome-wide association studies are promising for unraveling the genetic basis of complex diseases. Population structure is a potential problem, the effects of which on genetic association studies ...
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Article
Open AccessA new transmission test for affected sib-pair families
Family-based association approaches such as the transmission-disequilibrium test (TDT) are used extensively in the study of genetic traits because they are generally robust to the presence of population struct...
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Article
Parent–child pair design for detecting gene–environment interactions in complex diseases
It is becoming clear that the etiology of complex diseases involves not only genetic and environmental factors but also gene–environment (GE) interactions. Therefore, it is important to take account of all the...
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Article
Open AccessCOGA phenotypes and linkages on chromosome 2
An initial linkage analysis of the alcoholism phenotype as defined by DSM-III-R criteria and alcoholism defined by DSM-IV criteria showed many, sometimes striking, inconsistencies. These inconsistencies are gr...
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Article
Map** Multiple Quantitative Trait Loci for Ordinal Traits
Many complex traits in humans and other organisms show ordinal phenotypic variation but do not follow a simple Mendelian pattern of inheritance. These ordinal traits are presumably determined by many factors, ...
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Article
Open AccessColon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients
Proper histomorphological interpretation of intestinal acute graft versus host disease (A-GVHD) associated with allogeneic bone marrow transplantation (BMT) is critical for clinical managaement. However, studi...
