56 Result(s)

Article

Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice

H7N9 subtype avian influenza viruses (AIVs) cause 1567 human infections and have high mortality, posing a significant threat to public health. Previously, we reported that two avian-derived H7N9 isolates (A/ch...

**aoquan Wang, **n-en Tang, Huafen Zheng, Ruyi Gao, **aolong Lu… in Veterinary Research (2024)

Article

Bacterial c-di-GMP triggers metamorphosis of mussel larvae through a STING receptor

Bacteria induced metamorphosis observed in nearly all marine invertebrates. However, the mechanism of bacteria regulating the larvae-juvenile metamorphosis remains unknown. Here, we test the hypothesis that c-...

**ao-Meng Hu, Lihua Peng, Yuyi Wang, Fan Ma, Yu Tao… in npj Biofilms and Microbiomes (2024)

Article

The haemagglutinin–neuraminidase protein of velogenic Newcastle disease virus enhances viral infection through NF-κB-mediated programmed cell death

The haemagglutinin–neuraminidase (HN) protein, a vital membrane glycoprotein, plays a pivotal role in the pathogenesis of Newcastle disease virus (NDV). Previously, we demonstrated that a mutation in the HN pr...

**aolong Lu, Tiansong Zhan, Qiwen Zhou, Wenhao Yang, Kaituo Liu… in Veterinary Research (2024)

Article

Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo

Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated in light of global malaria elimination goals. They potentially undermine malaria interventions but remain an overlooked aspect of publ...

Nadine Kalenda Kayiba, Yuko Nitahara, Evariste Tshibangu-Kabamba… in Malaria Journal (2024)

Article

Adaptive responses of erythritol-producing Yarrowia lipolytica to thermal stress after evolution

Elucidation of the thermotolerance mechanism of erythritol-producing Yarrowia lipolytica is of great significance to breed robust industrial strains and reduce cost. This study aimed to breed thermotolerant Y. li...

Kai **a, Yuqing Chen, Fangmei Liu, Xuequn Zhao… in Applied Microbiology and Biotechnology (2024)

Article

Cellular vimentin regulates the infectivity of Newcastle disease virus through targeting of the HN protein

The haemagglutinin-neuraminidase (HN) protein plays a crucial role in the infectivity and virulence of Newcastle disease virus (NDV). In a previous study, the mutant HN protein was identified as a crucial viru...

**aolong Lu, Kaituo Liu, Yu Chen, Ruyi Gao, Zenglei Hu, Jiao Hu… in Veterinary Research (2023)

Article

Malaria epidemiological characteristics and control in Guangzhou, China, 1950–2022

Malaria was once widespread in Guangzhou, China. However, a series of control measures have succeeded in eliminating local malaria infections. Based on the analysis of the characteristics of malaria epidemics ...

Yuehua Chen, Hao Zhang, Haiyan Chen, Lirui Fan, Conghui Xu, Jianmin Xu… in Malaria Journal (2023)

Article

The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo

Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen with the characteristics of high mortality and morbidity, which brings great challenges to prevent and control epidemic disease in the swine i...

Yi Lu, Fa **ang, Liuyi Xu, Hongliang Tian, Qi Tao, Kaixiang Jia… in Veterinary Research (2023)

Article

NAD⁺ metabolism-based immunoregulation and therapeutic potential

Nicotinamide adenine dinucleotide (NAD⁺) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD⁺-dependent enzymes, including sirtuins, CD38 and poly(...

Jiankai Fang, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo… in Cell & Bioscience (2023)

Article

Determining the changes in metabolites of Dendrobium officinale juice fermented with starter cultures containing Saccharomycopsis fibuligera FBKL2.8DCJS1 and Lactobacillus paracasei FBKL1.3028 through untargeted metabolomics

The present study aimed to investigate the changes in volatile components and metabolites of Dendrobium officinale (D. officinale) juice fermented with starter cultures containing Saccharomycopsis fibuligera and

Wanlin Liu, **aoye Luo, Shuyi Qiu, Wu Huang, Yanan Su, Linling LI in BMC Microbiology (2023)

Article

Correction: Significant alterations of intestinal symbiotic microbiota induced by intraperitoneal vaccination mediate changes in intestinal metabolism of NEW Genetically Improved Farmed Tilapia (NEW GIFT, Oreochromis niloticus)

Zhenbing Wu, Qianqian Zhang, Jicheng Yang, **yong Zhang, Jie Fu… in Microbiome (2023)

Article

VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α

Renal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are currently no nephroprotective drugs targeted to the fibrotic process ...

Jiayi Yang, Yuyi Ruan, Dan Wang, **** Fan, Ning Luo, Huiting Chen… in Cell & Bioscience (2022)

Article

Significant alterations of intestinal symbiotic microbiota induced by intraperitoneal vaccination mediate changes in intestinal metabolism of NEW Genetically Improved Farmed Tilapia (NEW GIFT, Oreochromis niloticus)

After millions of years of coevolution, symbiotic microbiota has become an integral part of the host and plays an important role in host immunity, metabolism, and health. Vaccination, as an effective means of ...

Zhenbing Wu, Qianqian Zhang, Jicheng Yang, **yong Zhang, Jie Fu… in Microbiome (2022)

Article

Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial

Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for improved vaccine design. We analysed binding and neutralizing antibody measurements 4 ...

Youyi Fong, Adrian B. McDermott, David Benkeser, Sanne Roels… in Nature Microbiology (2022)

Article

Publisher Correction: Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

Johanna Rhodes, Alireza Abdolrasouli, Katie Dunne, Thomas R. Sewell… in Nature Microbiology (2022)

Article

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...

Ruvishika S. Jayawardena, Kevin D. Hyde, Song Wang, Ya-Ru Sun… in Fungal Diversity (2022)

Article

A microfluidic paper analytical device using capture aptamers for the detection of PfLDH in blood matrices

The prevalence and death rate arising from malaria infection, and emergence of other diseases showing similar symptoms to malaria require the development of malaria-specific and sensitive devices for its diagn...

Adewoyin Martin Ogunmolasuyi, Ronen Fogel, Heinrich Hoppe, Dean Goldring… in Malaria Journal (2022)

Article

Ginkgolic acid and anacardic acid are reversible inhibitors of SARS-CoV-2 3-chymotrypsin-like protease

Because of the emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different regions of the world, the battle with infectious coronavirus disease 2019 (COVID-19) caused by SARS...

Dongsheng Li, Gangan Yan, Wenwen Zhou, Shuyi Si, ** Liu… in Cell & Bioscience (2022)

Article

Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible pati...

Johanna Rhodes, Alireza Abdolrasouli, Katie Dunne, Thomas R. Sewell… in Nature Microbiology (2022)

Article

Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population

Vaginal microbiota-host interactions are linked to preterm birth (PTB), which continues to be the primary cause of global childhood mortality. Due to population size, the majority of PTB occurs in Asia, yet th...

Sherrianne Ng, Muxuan Chen, Samit Kundu, Xuefei Wang… in npj Biofilms and Microbiomes (2021)