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Article
Open AccessQuantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
In the ENSEMBLE randomized, placebo-controlled phase 3 trial (NCT04505722), estimated single-dose Ad26.COV2.S vaccine efficacy (VE) was 56% against moderate to severe–critical COVID-19. SARS-CoV-2 Spike sequen...
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Article
Highly adaptive regression trees
The development of machine learning methods that are both accurate and interpretable is of paramount importance in healthcare and many other fields. The Highly Adaptive Lasso (HAL) has been shown to have predi...
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Article
Open AccessExamining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration
While new vaccines for SARS-CoV-2 are authorized based on neutralizing antibody (nAb) titer against emerging variants of concern, an analogous pathway does not exist for preventative monoclonal antibodies. In ...
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Article
Open AccessPublisher Correction: Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial
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Article
Open AccessImmune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine
In the phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine conducted in the U.S., Chile, and Peru, anti-spike binding IgG concentration (spike IgG) and pseudovirus 50% neutralizing antibody titer (nAb ID50)...
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Article
Open AccessImmune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial
In the PREVENT-19 phase 3 trial of the NVX-CoV2373 vaccine (NCT04611802), anti-spike binding IgG concentration (spike IgG), anti-RBD binding IgG concentration (RBD IgG), and pseudovirus 50% neutralizing antibo...
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Article
Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial
Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for improved vaccine design. We analysed binding and neutralizing antibody measurements 4 ...
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Article
A two-stage super learner for healthcare expenditures
To improve the estimation of healthcare expenditures by introducing a novel method that is well-suited to situations where data exhibit strong skewness and zero-inflation. Simulations, and two real-world datas...
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Article
Design and Analysis Considerations for a Sequentially Randomized HIV Prevention Trial
The TechStep study is an ongoing randomized controlled trial in HIV-negative transgender youths and young adults, which will evaluate the efficacy of mobile health interventions for reducing risk behaviors. Se...
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Chapter
Targeted Estimation of Cumulative Vaccine Sieve Effects
Over the last century, effective vaccines have been developed for prevention of disease caused by many pathogens. However, effective vaccines have not yet been developed to prevent infection with the human imm...
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Chapter
Highly Adaptive Lasso (HAL)
In this chapter, we define a general nonparametric estimator of a d-variate function valued parameter ψ 0. This parameter is defined as a minimizer of an expectation of a loss function L(ψ)(O) that is guaranteed ...
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Chapter
Online Super Learning
We consider the case that the data O n = (O(1), …, O(n)) ∼ P 0 n is generated sequentially by a conditional probability distribution P θ, t ...
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Article
Open AccessCross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain
To compare accuracy measures for mammographic screening in Norway, Spain, and the US.
