-
Article
Open AccessOptimizing deep learning-based segmentation of densely packed cells using cell surface markers
Spatial molecular profiling depends on accurate cell segmentation. Identification and quantitation of individual cells in dense tissues, e.g. highly inflamed tissue caused by viral infection or immune reaction...
-
Article
Open AccessExamining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration
While new vaccines for SARS-CoV-2 are authorized based on neutralizing antibody (nAb) titer against emerging variants of concern, an analogous pathway does not exist for preventative monoclonal antibodies. In ...
-
Article
Open AccessPublisher Correction: Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial
-
Article
Open AccessImmune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine
In the phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine conducted in the U.S., Chile, and Peru, anti-spike binding IgG concentration (spike IgG) and pseudovirus 50% neutralizing antibody titer (nAb ID50)...
-
Article
Open AccessImmune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial
In the PREVENT-19 phase 3 trial of the NVX-CoV2373 vaccine (NCT04611802), anti-spike binding IgG concentration (spike IgG), anti-RBD binding IgG concentration (RBD IgG), and pseudovirus 50% neutralizing antibo...
-
Article
Immune correlates analysis of the ENSEMBLE single Ad26.COV2.S dose vaccine efficacy clinical trial
Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for improved vaccine design. We analysed binding and neutralizing antibody measurements 4 ...
-
Article
Fast estimation and choice of confidence interval methods for step regression
In this paper we propose a new fast grid search algorithm for finding the least square estimators of a step regression model. This algorithm makes it practical to compute resampling-based confidence intervals ...
-
Article
Vapour pressure deficit determines critical thresholds for global coffee production under climate change
Our understanding of the impact of climate change on global coffee production is largely based on studies focusing on temperature and precipitation, but other climate indicators could trigger critical threshol...
-
Article
Open AccessImproving random forest predictions in small datasets from two-phase sampling designs
While random forests are one of the most successful machine learning methods, it is necessary to optimize their performance for use with datasets resulting from a two-phase sampling design with a small number ...
-
Article
Estimation and inference for upper hinge regression models
We introduce a new type of threshold regression models called upper hinge models. Under this type of threshold models, there only exists an association between the predictor of interest and the outcome when th...
-
Article
Open AccessHAI and NAI titer correlates of inactivated and live attenuated influenza vaccine efficacy
High hemagglutination inhibition (HAI) and neuraminidase inhibition (NAI) titers are generally associated with reduced influenza risk. While repeated influenza vaccination reduces seroresponse, vaccine effecti...
-
Article
Open AccessEfficacy of a bivalent killed whole-cell cholera vaccine over five years: a re-analysis of a cluster-randomized trial
Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes could he...
-
Article
Open Accesschngpt: threshold regression model estimation and inference
Threshold regression models are a diverse set of non-regular regression models that all depend on change points or thresholds. They provide a simple but elegant and interpretable way to model certain kinds of ...
-
Article
Open AccessQuality control, analysis and secure sharing of Luminex® immunoassay data using the open source LabKey Server platform
Immunoassays that employ multiplexed bead arrays produce high information content per sample. Such assays are now frequently used to evaluate humoral responses in clinical trials. Integrated software is needed...
