122 Result(s)

Article

Role of Wnt canonical pathway in hematological malignancies

Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the patho...

Xueling GE, **n Wang in Journal of Hematology & Oncology (2010)

Article

Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia

To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia (SAA).

Fang Zhou, Linfu Ge, Zhe Yu, Yuan Fang, Fansheng Kong in Journal of Hematology & Oncology (2011)

Article

Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions

Erythropoietin (EPO) provides an alternative to transfusion for increasing red blood cell mass and treating anemia in cancer patients. However, recent studies have reported increased adverse events and/or redu...

Makito Miyake, Steve Goodison, Adrienne Lawton… in Journal of Hematology & Oncology (2013)

Article

CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, ...

Wenxiu Qi, Chengzhi **e, Chunhuai Li… in Journal of Hematology & Oncology (2014)

Article

Phase I/II study of adjuvant immunotherapy with sentinel lymph node T lymphocytes in patients with colorectal cancer

Although the development of multi-disciplinary management has improved the survival of colorectal cancer (CRC), the prognosis of metastatic CRC patients remains poor. Accumulating evidence has demonstrated tha...

Yun-Huan Zhen, **ao-Hui Liu, Yuan Yang, Bo Li… in Cancer Immunology, Immunotherapy (2015)

Article

NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin

Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine kinase that regulates the activity of a wide range of signal transduction pathways. Metformin, an oral antidiabetic drug, is used for canc...

Dong Suwei, Zeng Liang, Liu Zhimin, Li Ruilei… in Journal of Hematology & Oncology (2015)

Article

Erratum to: NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin

Dong Suwei, Zeng Liang, Liu Zhimin, Li Ruilei… in Journal of Hematology & Oncology (2016)

Article

Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia

C Song, X Pan, Z Ge, C Gowda, Y Ding, H Li, Z Li, G Yochum, M Muschen, Q Li… in Leukemia (2016)

Article

MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that ...

Pei Li, Yang Yang, Hui Liu, An-Kui Yang, **-Ming Di… in Journal of Hematology & Oncology (2017)

Article

Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy (usually cytarabine) often deve...

Daniel A Luedtke, **aojia Niu, Yihang Pan… in Signal Transduction and Targeted Therapy (2017)

Article

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1

Regulatory T cells (Treg) hamper anti-tumor T-cell responses resulting in reduced survival and failure of cancer immunotherapy. Among lymphoid organs, the bone marrow (BM) is a major site of Treg residence and...

Anchana Rathinasamy, Christoph Domschke, Yingzi Ge… in Cancer Immunology, Immunotherapy (2017)

Article

Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated th...

Hua Guo, Yangyang Ge, **ao** Li, Yanlian Yang… in Signal Transduction and Targeted Therapy (2017)

Article

An application study of low-dose computed tomography perfusion imaging for evaluation of the efficacy of neoadjuvant chemotherapy for advanced gastric adenocarcinoma

This study used low-dose computed tomography (CT) perfusion imaging technology to evaluate the efficacy of neoadjuvant chemotherapy in patients with advanced gastric adenocarcinoma and to determine whether any...

Zongqiong Sun, **aofang Cheng, Yuxi Ge, Lin Shao, Yinghua Xuan, Gen Yan in Gastric Cancer (2018)

Article

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study

In myelodysplastic syndromes (MDS), health-related quality of life (HRQoL) represents a relevant patient-reported outcome, which is essential in individualized therapy planning. Prospective data on HRQoL in lo...

Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux… in Leukemia (2018)

Article

Asymptomatic versus symptomatic solid pseudopapillary tumors of the pancreas: clinical and MDCT manifestations

To delineate the features of multi-detector computed tomography (MDCT) images and clinical characteristics of pancreatic solid pseudopapillary tumors (SPTs) of the pancreas in asymptomatic patients and compare...

Shudong Hu, Heng Zhang, **an Wang, Zongqiong Sun, Yuxi Ge, Gen Yan… in Cancer Imaging (2019)

Article

Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang, Margaret Shatara, Fangbing Liu… in Signal Transduction and Targeted Therapy (2019)

Article

Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features

Hepatoid adenocarcinoma of the stomach (HAS) is characterized by histological resemblance to hepatocellular carcinoma and a poor prognosis. The aim of this study is to elucidate the clinicopathological and mol...

Yakun Wang, Li Sun, Zhongwu Li, **g Gao, Sai Ge, Cheng Zhang… in Gastric Cancer (2019)

Article

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros regulates gene expression and cellular proliferation ...

Yali Ding, Bo Zhang, Jonathon L. Payne, Chunhua Song, Zheng Ge, Chandrika Gowda… in Leukemia (2019)

Article

Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia

Shifen Wang, Maolin Ge, **g Cui, Zhi Qiao, **uli Chen, Shunquan Wu, Rong Zhan… in Leukemia (2019)

Article

Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia

Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall res...

Daniel A. Luedtke, Yongwei Su, Jun Ma, **nyu Li… in Signal Transduction and Targeted Therapy (2020)