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Article
Terminus-immobilization effect on peptide conformations and peptide–peptide interactions
Peptide-modified delivery systems are enabling the improvement of the targeting specificity, biocompatibility, stability, etc. However, the precise design of a peptide-decorated surface for a designated functi...
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Article
Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy
Chemotherapy remains one of the most prevailing strategies for cancer treatment. However, its treatment effect is hampered by drug resistance, nonspecific tumor targeting, and severe toxic side effects. Combin...
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Article
Principles of amino-acid–ribonucleotide interaction revealed by binding affinities between homogeneous oligopeptides and single-stranded RNA molecules
We have determined the binding strengths between ribonucleotides of adenine (A), guanine (G), uracil (U), and cytosine (C) in homogeneous single-stranded ribonucleic acids (ssRNAs) and homo-decapeptides consis...
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Article
Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy
Precise imaging is essential for the accurate diagnosis and surgical guidance of brain diseases but it is challenging due to the difficulties in crossing the blood-brain barrier (BBB), the difficulties in dise...
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Article
Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition
Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging due to the lack of high-resolution, easy-to-operate, and fas...
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Article
Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide
Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability, offering an alternative for reversing drug resistance in cancer therapy. Herein, a formulate...
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Article
Efficacy relevance of PD-L1 expression on circulating tumor cells in metastatic breast cancer patients treated with anti-PD-1 immunotherapy
Breast cancer has become the leading cause of cancer mortality in women. Although immune checkpoint inhibitors targeting programmed death-1 (PD-1) are promising, it remains unclear whether PD-L1 expression on ...
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Article
A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging
Hepatobiliary magnetic resonance imaging (MRI) can inform the diagnosis of liver tumours in patients with liver cirrhosis and hepatitis. However, its clinical utility has been hampered by the lack of sensitive...
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Article
Open AccessA novel CD123-targeted therapeutic peptide loaded by micellar delivery system combats refractory acute myeloid leukemia
Acute myeloid leukemia (AML) is a common malignant heterogeneous hematopoietic disease with very low average 5-year survival rate due to the refractory feature and high rate of relapse. CD123 is highly express...
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Chapter
Molecular Studies of Peptide Assemblies and Related Applications in Tumor Therapy and Diagnosis
Peptides and proteins are known to form a variety of aggregate forms via assembling processes with significant dependence on sequences, which is characteristic for amyloid-like structures. Such peptides could ...
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Article
Vacuum-tuned-atmosphere induced assembly of Au@Ag core/shell nanocubes into multi-dimensional superstructures and the ultrasensitive IAPP proteins SERS detection
Utilizing vacuum-tuned-atmosphere induced dip coating method, we achieve the cross-dimensional macroscopic diverse self-assemblies by using one building block with one chemical functionality. Coordinated modul...
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Chapter
Peptide Self-Assembly and Its Modulation: Imaging on the Nanoscale
This chapter intends to review the progress in obtaining site-specific structural information for peptide assemblies using scanning tunneling microscopy. The effects on assembly propensity due to mutations and...
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Article
Open AccessSingle-molecule insights into surface-mediated homochirality in hierarchical peptide assembly
Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at t...
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Article
Probing Molecular Basis for Constructing Interface Bionanostructures
Understanding the interface of bionanostructures is crucial for novel biomedical applications. In this review, we endeavor to reflect the recent progress on molecular features of interfacial behavior of peptid...
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Article
Liquid Exfoliation of Few-layer 1T-TaS2−x Se x Superconductors
Atomic layer superconductors (ALSCs) have been applied in studying many quantum phenomena over the past ten years. However, self-standing ALSCs beyond the conventional substrates have not been developed yet ex...
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Article
Open AccessDual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide
The oligomerization and fibrillation of human islet amyloid polypeptide (hIAPP) play a central role in the pathogenesis of type 2 diabetes. Strategies for remodelling the formation of hIAPP oligomers and fibri...
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Article
Open AccessAuthor Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy
For the design and optimization of functional peptides, unravelling the structures of individual building blocks as well as the properties of the ensemble is paramount. TTR1, derived from human transthyretin, ...
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Article
Open AccessUnraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer. Systematic comparison of their...
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Article
Open AccessTargeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression
Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated th...
