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Article
Open AccessPAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity
The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator, impacting fibrinolysi...
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Article
Open AccessDiagnostic performance of Oncuria™, a urinalysis test for bladder cancer
Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease ha...
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Article
An efficient and effective method to identify significantly perturbed subnetworks in cancer
The identification of key functional biological networks from high-dimensional genomics data is pivotal for cancer research. Here, we introduce FDRnet, a method for the detection of molecular subnetworks in ca...
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Article
Open AccessPrognostic cancer gene signatures share common regulatory motifs
Scientists have discovered various prognostic gene signatures (GSs) in different cancer types. Surprisingly, although different GSs from the same cancer type can be used to measure similar biological character...
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Article
Open AccessA multiplex urinary immunoassay for bladder cancer detection: analysis of a Japanese cohort
Bladder cancer (BCa) is among the most commonly diagnosed malignancies worldwide, and due the high rate of post-operative disease recurrence, it is one of the most prevalent in many countries. The development ...
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Article
Open AccessA multiplex immunoassay for the non-invasive detection of bladder cancer
Urine based assays that can non-invasively detect bladder cancer (BCa) have the potential to reduce unnecessary and invasive procedures. The purpose of this study was to develop a multiplex immunoassay that ca...
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Article
Open AccessValidation and clinicopathologic associations of a urine-based bladder cancer biomarker signature
To validate the expression of a urine-based bladder cancer associated diagnostic signature comprised of 10 targets; ANG, CA9, MMP9, MMP10, SERPINA1, APOE, SDC1, VEGFA, SERPINE1 and IL8 in bladder tumor tissues.
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Article
Open AccessCancer progression modeling using static sample data
As molecular profiling data continue to accumulate, the design of integrative computational analyses that can provide insights into the dynamic aspects of cancer progression becomes feasible. Here, we present ...
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Article
Deleted in Liver Cancer-1 (DLC1): An Emerging Metastasis Suppressor Gene
While significant progress continues to be made in the early detection and therapeutic management of primary tumors, the incidence of metastatic disease remains the major cause of mortality. Accordingly, the d...
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Article
Open AccessMatrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors
Cancer invasion and metastasis develops through a series of steps that involve the loss of cell to cell and cell to matrix adhesion, degradation of extracellular matrix and induction of angiogenesis. Different...
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Article
Open AccessSimultaneous multi-analyte urinary protein assay for bladder cancer detection
The ability to accurately measure multiple proteins simultaneously in a single assay has the potential to markedly improve the efficiency of a myriad of clinical assays. Here, we tested the performance of a ne...
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Article
Open AccessClinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer
To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder.
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Open AccessInvestigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection
In this study, we further investigated the association of two biomarkers, CCL18 and A1AT, with bladder cancer (BCa) and evaluated the influence of potentially confounding factors in an experimental model.
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Article
Open AccessErythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions
Erythropoietin (EPO) provides an alternative to transfusion for increasing red blood cell mass and treating anemia in cancer patients. However, recent studies have reported increased adverse events and/or redu...
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Article
Open AccessChemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers
Chemokines, including chemokine (C-X-C motif) ligand 1 (CXCL1), may regulate tumor epithelial-stromal interactions that facilitate tumor growth and invasion. Studies have linked CXCL1 expression to gastric, co...
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Article
Open AccessBladder Cancer Detection and Monitoring: Assessment of Urine- and Blood-Based Marker Tests
Bladder cancer is one of the most prevalent cancers worldwide, but the treatment and management of this disease can be very successful if the disease is detected early. The development of molecular assays that...
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Article
Urinary BTA: indicator of bladder cancer or of hematuria
In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model.
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Open AccessInfluencing factors on the NMP-22 urine assay: an experimental model
The commercial NMP-22 urine assays for bladder cancer (BCa) detect nuclear mitotic apparatus protein 1 (NUMA1) using monoclonal antibodies. It remains unclear whether these assays are monitoring a tumor antige...
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Article
Open AccessIL-8 as a urinary biomarker for the detection of bladder cancer
Current urine-based assays for bladder cancer (BCa) diagnosis lack accuracy, so the search for improved biomarkers continues. Through genomic and proteomic profiling of urine, we have identified a panel of bio...
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Article
Open AccessProduction of IL1-beta by ovarian cancer cells induces mesothelial cell beta1-integrin expression facilitating peritoneal dissemination
A crucial step in the metastatic spread of ovarian cancer (OC) is the adhesion and implantation of tumor cells to the peritoneal mesothelium. In order to study this step in the cascade, we derived a pro-metast...
