31 Result(s)
within
**ehua Zhang
Life Sciences
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Article
Role of sugars in the apical hook development of Arabidopsis etiolated seedlings
The sugar supply in the medium affects the apical hook development of Arabidopsis etiolated seedlings. In addition, we provided the mechanism insights of this process.
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Article
Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...
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Article
Clinical and functional consequences of GRIA variants in patients with neurological diseases
AMPA receptors are members of the glutamate receptor family and mediate a fast component of excitatory synaptic transmission at virtually all central synapses. Thus, their functional characteristics are a crit...
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Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology, molecular dynamics simulations, and in vitro experiments
This study built a prognostic model for CRC-diabetes and analyzed whether quercetin could be used for CRC-diabetes treatment through a network of pharmacology, molecular dynamics simulation, bioinformatics, an...
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Open AccessA LlMYB305-LlC3H18-LlWRKY33 module regulates thermotolerance in lily
The CCCH proteins play important roles in plant growth and development, hormone response, pathogen defense and abiotic stress tolerance. However, the knowledge of their roles in thermotolerance are scarce. Her...
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Redesign of γ-glutamyl transpeptidase from Bacillus subtilis for high-level production of L-theanine by cavity topology engineering
L-Theanine is a multifunctional nonprotein amino acid found naturally in tea leaves. It has been developed as a commercial product for a wide range of applications in the food, pharmaceutical, and healthcare i...
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Article
Open AccessImproving ethanol tolerance of ethyl carbamate hydrolase by diphasic high pressure molecular dynamic simulations
Ethyl carbamate (EC) is mainly found in fermented foods and fermented alcoholic beverages, which could cause carcinogenic potential to humans. Reducing EC is one of the key research priorities to address secur...
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Article
Anti-biofilm activity of biochanin A against Staphylococcus aureus
Biofilm-forming Staphylococcus aureus can easily accumulate on various food contact surfaces which induce cross-contamination and are difficult to eliminate in the food industry. This study aimed to evaluate the ...
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Comparing the effectiveness of R genes in a 2-year canola–wheat rotation against Leptosphaeria maculans, the causal agent of blackleg disease in Brassica species
Blackleg, which is caused by the ascomycete fungus Leptosphaeria maculans, is a major disease of canola in Canada and worldwide. In Canada, canola is usually grown in rotation once every three to four years to li...
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Article
Open AccessIdentification and validation of QTLs for kernel number per spike and spike length in two founder genotypes of wheat
Kernel number per spike (KNS) and spike length (SL) are important spike-related traits in wheat variety improvement. Discovering genetic loci controlling these traits is necessary to elucidate the genetic basi...
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Open AccessA novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway
SATB2-associated syndrome (SAS) is a multisystem disorder caused by mutation of human SATB2 gene. Tooth agenesis is one of the most common phenotypes observed in SAS. Our study aimed at identifying novel variant ...
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Article
Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAATβ axis
Resistance to chemotherapy drugs is a major factor affecting the surgical outcome and prognosis of osteosarcoma patients. Circular RNAs (circRNAs) play an important role in tumor resistance to chemotherapy. In...
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Article
The downregulation of PpPG21 and PpPG22 influences peach fruit texture and softening
The downregulation of PpPG21 and PpPG22 expression in melting-flesh peach delays fruit softening and hinders texture changes by influencing pectin solubilization and depolymerization.
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Open AccessDeconstructing transcriptional variations and their effects on immunomodulatory function among human mesenchymal stromal cells
Mesenchymal stromal cell (MSC)-based therapies are being actively investigated in various inflammatory disorders. However, functional variability among MSCs cultured in vitro will lead to distinct therapeutic ...
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Article
The survival, growth, and detoxifying enzyme activities of grasshoppers Oedaleus asiaticus (Orthoptera: Acrididae) exposed to toxic rutin
Secondary compounds from plants are often insecticidal. Rutin, a plant bioflavonoid, has demonstrated insect control activity. We studied the survival, growth, and detoxifying enzyme activities of grasshopper Oed...
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Article
Inhibitory effect of genistein and PTP1B on grasshopper Oedaleus asiaticus development
Protein tyrosine kinase (PTKs) and protein tyrosine phosphatase (PTPs) collectively regulate the insect insulin-signaling pathway (ISP), cell growth, metabolism, proliferation, differentiation, cell communicat...
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Article
Open AccessIdentification of resistance loci in Chinese and Canadian canola/rapeseed varieties against Leptosphaeria maculans based on genome-wide association studies
The fungal pathogen Leptosphaeria maculans (Lm). causes blackleg disease on canola/rapeseed in many parts of the world. It is important to use resistant cultivars to manage the disease and minimize yield losses. ...
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Article
Comparative Efficacy of Leaf Extracts of Different Tobacco Varieties Against Mustard Aphid (Lipaphis erysimi Kalt.)
In this study, field and laboratory experiments were carried out in order to develop a biological control strategy against mustard aphid by using extracts of five tobacco varieties (Beeri wala, Balkhi, Pattay ...
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Open AccessPlant composition changes in a small-scale community have a large effect on the performance of an economically important grassland pest
The grasshopper Oedaleus asiaticus Bey-Bienko (Acrididae: Oedipodinae) is a dominant and economically important pest that is widely distributed across the Mongolian plateau. This herbivore pest causes major damag...
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Decreasing sulfide in sediment and promoting plant growth by plant–sediment microbial fuel cells with emerged plants
Four plant–sediment microbial fuel cells (plant-SMFCs) with four plant species, Oryza sativa, Acorus calamus, Spathiphyllum petite and Chamaedorea elegans, were built to investigate sulfide concentrations, pH and...
