48 Result(s)
within
**ao-juan Li
Biomedicine, general
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Article
Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro
To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY20 in insulin-sensitive cell lines.
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Article
Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines
Comparative proteomics provide a powerful approach in screening for alterations in protein levels and post-translational modifications that are associated with tumors. In the present study, we aimed to identif...
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Article
Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7
To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.
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Article
Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells
Neurite outgrowth and neuronal differentiation play a crucial role in the development of the nervous system. Understanding of neurotrophins induced neurite outgrowth was important to develop therapeutic strate...
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Article
The association of CaM and Hsp70 regulates S-phase arrest and apoptosis in a spatially and temporally dependent manner in human cells
The cell cycle is controlled by regulators functioning at the right time and at the right place. We have found that calmodulin (CaM) has specific distribution patterns during different cell-cycle stages. Here,...
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Article
Synthesis and Fluorescence Properties of Lanthanide (III) Perchlorate Complexes with Naphthyl-Naphthalinesulphonylpropyl Sulfoxide
A ligand with double sulfinyl groups, naphthyl-naphthalinesulphonylpropyl sulfoxide(dinaphthyl disulfoxide, L), was synthesized by a new method and its several lanthanide (III) complexes were synthesized and c...
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Article
The Studies of Enhanced Fluorescence in the Two Novel Ternary Rare-Earth Complex Systems
Two novel ternary rare-earth complexes SmL5·L’·(ClO4)2·7H2O and EuL5·L’·(ClO4)2·6H2O (the first ligand L = C6H5COCH2SOCH2COC6H5, the second ligand L’ = C6H4OHCOO−) were synthesized and characterized by element an...
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Article
Synthesis and Luminescence Properties of Two Novel Lanthanide (III) Perchlorate Complexes with Bis(benzoylmethyl) Sulfoxide and Benzoic Acid
Two novel ternary rare earth complexes of Tb(III) and Dy(III) perchlorates with bis(benzoylmethyl) sulfoxide (L) and benzoic acid (L′) had been synthesized and characterized by elemental analysis, coordination...
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Article
Open AccessCo-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer
The intratumoral infiltration of T cells, especially memory T cells, is associated with a favorable prognosis in early colorectal cancers. However, the mechanism underlying this process remains elusive. This s...
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Article
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of DNMT3A, which encodes a DNA methyltransferase,...
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Article
Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5
The mitotic kinesin Eg5 plays a critical role in bipolar spindle assembly, and its inhibitors have shown impressive anticancer activity in preclinical studies. This study was undertaken to investigate the effe...
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Article
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy
In mouse models, the authors find that NRG1–ErbB4 signaling contributes to epilepsy through regulating the excitability of fast-spiking parvalbumin interneurons. ErbB4 expression was also reduced in human epil...
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Article
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously rep...
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Article
Open AccessSurvivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells
Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is ov...
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Article
Open AccessRoles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma
Linker for activation of T cells (LAT), a transmembrane adaptor protein, plays a role in T cell and mast cell function, while it remains unclear how histone modifications mediate LAT expression in allergic ast...
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Article
Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation
Sinomenine (SIN) is an alkaloid found in the roots and stems of Sinomenium acutum, which has been used to treat rheumatic arthritis in China and Japan. In this study we investigated the effects of SIN on osteocla...
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Article
Open AccessMetallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation
Acute myeloid leukemia (AML) is the second most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature in various tumors, including AML. Metallothionein III (MT3) i...
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Article
Molecular network-based analysis of Guizhi-Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy
Guizhi-Shaoyao-Zhimu decoction (GSZ), a traditional Chinese medicine (TCM) herbal formula, has been shown effective in the treatment of diabetic peripheral neuropathy (DPN). In this study, network analysis was...
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Article
Open AccessHypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) is the second-most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature of AML. GATA4 has been suggested to be a tumor suppressor gen...
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Article
Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression
Aconiti Lateralis Radix Preparata is a traditional Chinese medicine used to treat chronic arthritis and is highly effective against rheumatoid arthritis. However, the effects of aconine, a derivative of aconitum ...
