66 Result(s)
within
**ao-fu Dai
English
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Article
Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways
Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study elucidates the impact of α-Klotho, an anti-aging hormone, on ...
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A New Prenylated Hydroquinone from the Fruiting Bodies of Ganoderma calidophilum
Prenylated hydroquinones are the main meroterpenoids found in fungal species of the genus Ganoderma. A new prenylated hydroquinone ganocalidin G (1) was isolated from the fruiting bodies of Ganoderma calidophilum
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Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Open AccessAnti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage...
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Open AccessQuality of life in young patients with acute type a aortic dissection in China: comparison with Marfan syndrome and non-Marfan syndrome
There is a paucity of Chinese studies evaluating the quality of life (QoL) in young acute type A aortic dissection (AAAD) patients with Marfan syndrome.
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A New Macrolide from the Strain Cordyceps spp. from Cell Fusion between Cordyceps militaris and Cordyceps cicadae
A new macrolide cephalolidedifuran A (1), together with two known cephalosporolides B (2), and I (3), was isolated from the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyce...
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Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study
Current guidelines discourage the use of direct-acting antiviral (DAA) containing protease-inhibitor (PI) in advanced HCV cirrhosis. We aimed to compare the real-world tolerability of PI vs. non-PI DAA regimen...
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Article
Effectiveness and safety of 8-week glecaprevir/pibrentasvir in HCV treatment-naïve patients with compensated cirrhosis: real-world experience from Taiwan nationwide HCV registry
Large-scale real-world data of the 8-week glecaprevir/pibrentasvir (GLE/PIB) therapy for treatment-naïve patients of chronic hepatitis C virus (HCV) infection with compensated cirrhosis is scarce.
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Open AccessContinuous dynamic identification of key genes and molecular signaling pathways of periosteum in guided bone self-generation in swine model
Guided bone self-generation with periosteum-preserved has successfully regenerated mandibular, temporomandibular and interphalangeal joint. The aim of this study was to investigate the dynamic changes of gene ...
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Open AccessGenetic variations in patient with Parry–Romberg syndrome
Parry–Romberg syndrome is a rare craniofacial disorder which is characterized by progressive facial atrophy. The etiology and pathogenesis of the disease are not known. Herein, we report the genetic variants i...
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Open AccessImpact of frailty status on clinical and functional outcomes after concomitant valve replacement and bipolar radiofrequency ablation in patients aged 65 years and older
To evaluate the prognostic value of frailty in older recipients of concomitant valve replacement (VR) and bipolar radiofrequency ablation (BRFA), we examined whether clinical and functional outcomes differed b...
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Open AccessDo obese patients benefit from isolated aortic valve replacement through a partial upper sternotomy?
Controversial opinions exist for aortic valve replacement (AVR) through partial upper sternotomy in obese patients. Moreover, this study sought to investigate the potential clinical advantage of partial upper ...
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Open AccessDynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model
To investigate the dynamic expression of NFAT family of periosteum in guided bone regeneration process.
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Article
Open AccessImpact of minimally invasive mitral valve surgery on sexual dysfunction in male patients
Sexual dysfunction after cardiac surgery can seriously affect patients’ quality of life, but the impact of cardiac surgery on sexual function has long been neglected. Compared with conventional cardiac surgery...
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Article
Apatite chemistry as a petrogenetic–metallogenic indicator for skarn ore-related granitoids: an example from the Daye Fe–Cu–(Au–Mo–W) district, Eastern China
The Daye district represents one of the largest concentrations of skarn deposits in eastern China. There are two major types of skarn deposits (Fe skarn vs. Cu skarn) within this district, both genetically rel...
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Open AccessMetabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derang...
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Open AccessDetection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial
It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...
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Open AccessOpen Seldinger-guided peripheral femoro-femoral cannulation technique for totally endoscopic cardiac surgery
The cannulation technique used in totally endoscopic cardiac surgery has a significant impact on the overall prognosis of patients. However, there are no large cohort studies to discuss it. Here we report on o...
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Article
Sterols from the Fruiting Bodies of Haddowia longipes
A new sterol, named 6β-methoxyergosta-7,9(11),22E-triene-3β,5α-diol (1), together with seven known ones (2–8), was isolated from the fruiting bodies of Haddowia longipes. Their structures were identified on the b...
