A new macrolide cephalolidedifuran A (1), together with two known cephalosporolides B (2), and I (3), was isolated from the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae. Their structures were identified on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay for anti-nematode activity of all the isolates showed that compounds 1 and 3 revealed moderate inhibitory activity against the nematode Panagrellus redivivus, with a mortality ratio of 48.35 and 59.16% at 2.5 mg/mL, respectively. Moreover, compounds 1–3 showed weak inhibitory activity against AChE at the concentration of 100 μM.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. Boonphong, P. Kittakoop, M. Isaka, D. Pittayakhajonwut, M. Tanticharoen, and Y. Thebtaranonth, J. Nat. Prod., 64, 965 (2001).
V. Rukachaisirikul, S. Pramjit, C. Pakawatchai, M. Isaka, and S. Supothina, J. Nat. Prod., 67, 1953 (2004).
Y. K. Rao, S. H. Fang, W. S. Wu, and Y. M. Tzeng, J. Ethnopharmacol., 131, 363 (2010).
M. Y. Lu, C. C. Chen, L. Y. Lee, T. W. Lin, and C. F. Kuo, J. Nat. Prod., 78, 2452 (2015).
J. M. Jia, X. C. Ma, C. F. Wu, L. J. Wu, and J. S. Hu, Chem. Pharm. Bull., 53, 582 (2005).
J. Wang, D. M. Zhang, J. F. Jia, Q. L. Peng, H. Y. Tian, L. Wang, and W. C. Ye, Fitoterapia, 97, 23 (2014).
J. W. Bok, L. Lermer, J. Chilton, H. G. Klingeman, and G. H. N. Towers, Phytochemistry, 51, 891 (1999).
M. Isaka, P. Chinthanom, P. Rachtawee, W. Somyong, J. J. Luangsa-ard, and N. L. Hywel-Jones, Phytochem. Lett., 6, 162 (2013).
H. M. T. B. Herath, M. Jacob, A. D. Wilson, H. K. Abbas, and N. P. D. Nanayakkara, Nat. Prod. Res., 27, 1562 (2013).
M. J. Ackland, J. R. Hanson, P. B. Hitchcock, R. P. Mabelis, and A. H. Ratcliffe, J. Chem. Soc. Perkin Trans. 1, 2755 (1984).
K. J. Harkala, L. Eppakayala, and T. C. Maringanti, Eur. J. Chem., 5, 127 (2014).
J. S. Li, C. F. Zhao, J. Liu, and Y. G. Du, Tetrahedron, 71, 3885 (2015).
O. C. Finch, D. P. Furkert, and M. A. Brimble, Tetrahedron, 70, 590 (2014).
G. L. Ellman, K. D. Courtney, V. J. Andres, and R. M. Featherstone, Biochem. Pharmacol., 7, 88 (1961).
Q. Y. Ma, S. Yang, S. Z. Huang, F. D. Kong, Q. Y. **e, H. F. Dai, Z. F. Yu, and Y. X. Zhao, Chem. Nat. Compd., 54, 710 (2018).
N. N. Yang, Q. Y. Ma, L. Yang, Q. Y. **e, F. D. Kong, H. F. Dai, Z. F. Yu, and Y. X. Zhao, Phytochem. Lett., 44, 106 (2021).
Acknowledgment
This research was supported by the National Natural Science Fund of China (81973568), Financial Fund of the Ministry of Agriculture and Rural Affairs, P. R. China (NFZX2021), China Agriculture Research System of MOF and MARA (CARS-21).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 53–55.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Yang, NN., Ma, QY., Yang, L. et al. A New Macrolide from the Strain Cordyceps spp. from Cell Fusion between Cordyceps militaris and Cordyceps cicadae. Chem Nat Compd 60, 61–64 (2024). https://doi.org/10.1007/s10600-024-04254-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-024-04254-1