16 Result(s)

Article

Multi-modal molecular determinants of clinically relevant osteoporosis subtypes

Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...

Chunchun Yuan, **ang-Tian Yu, **g Wang, Bing Shu, **ao-Yun Wang… in Cell Discovery (2024)

Article

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens current global Coronavirus (COVID-19) vaccine ...

Bingqing **a, **aoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang… in Cell Discovery (2023)

Article

DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0

Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...

Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, **n-Ke Yin… in Cell Death & Disease (2022)

Article

Chromosome-level genome assembly of Zizania latifolia provides insights into its seed shattering and phytocassane biosynthesis

Chinese wild rice (Zizania latifolia; family: Gramineae) is a valuable medicinal homologous grain in East and Southeast Asia. Here, using Nanopore sequencing and Hi-C scaffolding, we generated a 547.38 Mb chromos...

Ning Yan, Ting Yang, **u-Ting Yu, Lian-Guang Shang, De-** Guo… in Communications Biology (2022)

Article

MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly

Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently...

Yan Zhong, Ting Long, Chuan-Sha Gu, **g-Yi Tang… in Cell Death & Differentiation (2021)

Article

Cellular redox state as a critical factor in initiating early embryonic-like program in embryonic stem cells

Chao Zhang, Yao-Long Yan, **g Hao, Yangming Wang in Cell Discovery (2019)

Article

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

More and more evidence indicates that circular RNAs (circRNAs) have important roles in several diseases, especially in cancers. However, their involvement remains to be investigated in breast cancer. Through s...

Jian-Zhen Xu, Chang-Chun Shao, **ao-Jia Wang, **ng Zhao… in Cell Death & Disease (2019)

Article

Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring

Tree shrews have a close relationship to primates and have many advantages over rodents in biomedical research. However, the lack of gene manipulation methods has hindered the wider use of this animal. Spermat...

Chao-Hui Li, Lan-Zhen Yan, Wen-Zan Ban, Qiu Tu, Yong Wu, Lin Wang, Rui Bi… in Cell Research (2017)

Article

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is...

Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji **e… in Cell Death & Disease (2016)

Article

Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain...

Kong-Yan Wu, Guo-Long Zuo, **ao-Feng Li, Qing Ye, Yong-Qiang Deng… in Cell Research (2016)

Article

Comparative transcriptome analysis of tomato (Solanum lycopersicum) in response to exogenous abscisic acid

Abscisic acid (ABA) can regulate the expressions of many stress-responsive genes in plants. However, in defense responses to pathogens, mounting evidence suggests that ABA plays variable roles. Little informat...

Yan Wang, **ang Tao, **ao-Mei Tang, Liang **ao, Jiao-long Sun, Xue-Feng Yan… in BMC Genomics (2013)

Article

Genetic map of Triticum turgidumbased on a hexaploid wheat population without genetic recombination for D genome

A synthetic doubled-haploid hexaploid wheat population, SynDH1, derived from the spontaneous chromosome doubling of triploid F₁ hybrid plants obtained from the cross of hybrids Triticum turgidum ssp. durum line L...

Li Zhang, Jiang-Tao Luo, Ming Hao, Lian-Quan Zhang, Zhong-Wei Yuan… in BMC Genetics (2012)

Article

Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae

Three new phthalide derivatives (1-3) named 5-(3′-methyl-2′-butenyl)-2-hydroxy-3-methoxy-4-methylbenzoic acid (1), 5-(3′-carboxyl-3′-methyl-2E-allyloxy)-3-methoxy-4-methylphthalide (2) and 5-(3′,3′-dimethylallylo...

**ao-Long Yang, Su Zhang, Qiong-Bo Hu, Du-Qiang Luo… in The Journal of Antibiotics (2011)

Article

Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus

An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined th...

Du-Qiang Luo, Li-Yan Zhao, Yao-Long Shi, Hong-Liang Tang… in The Journal of Antibiotics (2009)