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Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently...
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Open AccessRole of TGFβ3-Smads-Sp1 axis in DcR3-mediated immune escape of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of tumour-associated mortality worldwide, but no significant improvement in treating HCC has been reported with currently available systemic therapies. Immunot...
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Open AccessRGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC
Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC...
