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Specialized appendages in fuxianhuiids and the head organization of early euarthropods
Chengjiangocaris kunmingensis sp. nov. and Fuxianhuia xiaoshibaensis sp. nov.— early Cambrian fuxianhuiid fossils from a new Lagerstätte in Yunnan, China—show that ancestral arthropods had cephalic organization t...
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Article
Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Article
Open AccessMorphology and growth speed of hcp domains during shock-induced phase transition in iron
Emergence and time evolution of micro-structured new-phase domains play a crucial role in determining the macroscopic physical and mechanical behaviors of iron under shock compression. Here, we investigate, th...
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Article
Open AccessArticulated Wiwaxia from the Cambrian Stage 3 **aoshiba Lagerstätte
Wiwaxia is a bizarre metazoan that has been interpreted as a primitive mollusc and as a polychaete annelid worm. Extensive material from the Burgess Shale provides a detailed picture of its morphology and ontogen...
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Open AccessNucleation and growth mechanisms of hcp domains in compressed iron
In our previous work, we have pointed out that the shock-induced phase transition in iron occurs with the help of interface energy which reduces the potential barrier between two phases. Here, through studying...
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Article
Open AccessDislocation creation and void nucleation in FCC ductile metals under tensile loading: A general microscopic picture
Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To d...
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Article
Open AccessLow c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas
Aberrant c-Met has been implicated in the development of many cancers. The objective of this study was to identify an unfavorable prognostic marker that might guide decisions regarding clinical treatment strat...
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Article
Open AccessA novel hepatovirus identified in wild woodchuck Marmota himalayana
Hepatitis A virus (HAV) is a hepatotropic picornavirus that causes acute liver disease worldwide. Here, we report on the identification of a novel hepatovirus tentatively named Marmota Himalayana hepatovirus (MHH...
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Open AccessPolarization-dependent interfacial coupling modulation of ferroelectric photovoltaic effect in PZT-ZnO heterostructures
Recently, ferroelectric perovskite oxides have drawn much attention due to potential applications in the field of solar energy conversion. However, the power conversion efficiency of ferroelectric photovoltaic...
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Article
Open AccessInsights into Adaptations to a Near-Obligate Nematode Endoparasitic Lifestyle from the Finished Genome of Drechmeria coniospora
Nematophagous fungi employ three distinct predatory strategies: nematode trap**, parasitism of females and eggs, and endoparasitism. While endoparasites play key roles in controlling nematode populations in ...
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Article
Open AccessRange wide molecular data and niche modeling revealed the Pleistocene history of a global invader (Halyomorpha halys)
Invasive species’ Pleistocene history contains much information on its present population structure, dispersability and adaptability. In this study, the Pleistocene history of a global invasive pest (Brown Mar...
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Open AccessNew Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
Eight highly oxygenated germacranolides (1–8) including four new ones (2–5) were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were...
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Article
Open AccessA predatory bivalved euarthropod from the Cambrian (Stage 3) **aoshiba Lagerstätte, South China
Bivalved euarthropods represent a conspicuous component of exceptionally-preserved fossil biotas throughout the Lower Palaeozoic. However, most of these taxa are known from isolated valves and thus there is a ...
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Open AccessMetabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway
Metabolomics can be used to identify potential markers and discover new targets for future therapeutic interventions. Here, we developed a novel application of the metabonomics method based on gas chromatograp...
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Open AccessIntegrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure o...
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Article
Open AccessA novel proposal of a simplified bacterial gene set and the neo-construction of a general minimized metabolic network
A minimal gene set (MGS) is critical for the assembly of a minimal artificial cell. We have developed a proposal of simplifying bacterial gene set to approximate a bacterial MGS by the following procedure. Fir...
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Open AccessNeuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia
Post-ischemic activation of NMDA receptors (NMDARs) has been linked to NMDAR subunit-specific signaling that mediates pro-survival or pro-death activity. Although extensive studies have been performed to chara...
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Article
Open AccessSham Electroacupuncture Methods in Randomized Controlled Trials
Sham electroacupuncture (EA) control is commonly used to evaluate the specific effects of EA in randomized-controlled trials (RCTs). However, establishing an inert and concealable sham EA control remains metho...
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Article
Open AccessFSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms
FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and ind...
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Open AccessPreoperative Heart Rate Variability as Predictors of Vagus Nerve Stimulation Outcome in Patients with Drug-resistant Epilepsy
Vagus nerve stimulation (VNS) is an adjunctive treatment for drug-resistant epilepsy (DRE). However, it is still difficult to predict which patients will respond to VNS treatment and to what extent. We aim to ...