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  1. No Access

    Article

    A 300 kilobase interval genetic map of rice including 883 expressed sequences

    We have constructed a high resolution rice genetic map containing 1,383 DNA markers at an average interval of 300 kilobases (kb). The markers, distributed along 1,575 cM on 12 linkage groups, comprise 883 cDNA...

    N. Kurata, Y. Nagamura, K. Yamamoto, Y. Harushima, N. Sue, J. Wu in Nature Genetics (1994)

  2. No Access

    Article

    Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

    Internalization of postsynaptic AMPA receptors depresses excitatory transmission, but the underlying dynamics and mechanisms of this process are unclear. Using immunofluorescence and surface biotinylation, we ...

    Jerry W. Lin, William Ju, Kelly Foster, Sang Hyoung Lee in Nature Neuroscience (2000)

  3. No Access

    Article

    Temporal and spatial expression of biologically active human factor VIII in the milk of transgenic mice driven by mammary-specific bovine α-lactalbumin regulation sequences

    Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concen...

    Chuan-Mu Chen, Chih-Hong Wang, Shinn-Chih Wu, Chih-Cheng Lin in Transgenic Research (2002)

  4. Article

    Genetic relationships among twelve Chinese indigenous goat populations based on microsatellite analysis

    Twelve Chinese indigenous goat populations were genotyped for twenty-six microsatellite markers recommended by the EU Sheep and Goat Biodiversity Project. A total of 452 goats were tested. Seventeen of the 26 ...

    Meng-Hua Li, Shu-Hong Zhao, Ci Bian, Hai-Sheng Wang in Genetics Selection Evolution (2002)

  5. No Access

    Article

    The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree

    A canine integrated linkage-radiation map has been recently constructed by using microsatellite markers. This map, with a good coverage of the canine genome, allows for a genome-wide search for the extent and ...

    **ang-Yang Lou, Rory J. Todhunter, Min Lin, Qing Lu, Tian Liu in Mammalian Genome (2003)

  6. No Access

    Article

    Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource

    Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical ...

    Wei Hu, Qing Yan, Da-Kang Shen, Feng Liu, Zhi-Dong Zhu, Huai-Dong Song in Nature Genetics (2003)

  7. Article

    Open Access

    Genetic variation and relationships of eighteen Chinese indigenous pig breeds

    Chinese indigenous pig breeds are recognized as an invaluable component of the world's pig genetic resources and are divided traditionally into six types. Twenty-six microsatellite markers recommended by the F...

    Shu-Lin Yang, Zhi-Gang Wang, Bang Liu, Gui-**ang Zhang in Genetics Selection Evolution (2003)

  8. Article

    Open Access

    Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches

    Current statistical methods for sib-pair linkage analysis of complex diseases include linear models, generalized linear models, and novel data mining techniques. The purpose of this study was to further invest...

    Zheng Guo, **a Li, Shaoqi Rao, Kathy L Moser, Tianwen Zhang, Binsheng Gong in BMC Genetics (2003)

  9. No Access

    Article

    Isolation and characterization of microsatellite loci in Acrossocheilus paradoxus (Cyprinidae) using PCR-based isolation of microsatellite arrays (PIMA)

    Kui-Ching Hsu, Jiang-** Wang, **ang-Lin Chen, Tzen-Yuh Chiang in Conservation Genetics (2004)

  10. No Access

    Article

    Predicted ATP-binding cassette systems in the phytopathogenic mollicute Spiroplasma kunkelii

    Spiroplasma kunkelii is a cell wall-free, helical, and motile mycoplasma-like organism that causes corn stunt disease in maize. The bacterium has a compact genome with a gene set approac...

    Y. Zhao, H. Wang, R. W. Hammond, R. Jomantiene, Q. Liu in Molecular Genetics and Genomics (2004)

  11. No Access

    Article

    Focal adhesion kinase in netrin-1 signaling

    Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the develo** nervous system. However, the signaling mechanisms that lie immediately downstream of netrin rec...

    **u-rong Ren, Guo-li Ming, Yi **e, Yan Hong, Dong-mei Sun in Nature Neuroscience (2004)

  12. No Access

    Article

    Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases

    Development of effective disease-resistance to a broad-range of pathogens in crops usually requires tremendous resources and effort when traditional breeding approaches are taken. Genetic engineering of diseas...

    Wan-Chi Lin, Ching-Fang Lu, Jia-Wei Wu, Ming-Lung Cheng, Yu-Mei Lin in Transgenic Research (2004)

  13. Article

    Open Access

    Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)

    Severe acute respiratory syndrome (SARS), a recent epidemic human disease, is caused by a novel coronavirus (SARS-CoV). First reported in Asia, SARS quickly spread worldwide through international travelling. A...

    Yun-Shien Lee, Chun-Houh Chen, Angel Chao, En-Shih Chen, Min-Li Wei in BMC Genomics (2005)

  14. No Access

    Article

    A rice quantitative trait locus for salt tolerance encodes a sodium transporter

    Many important agronomic traits in crop plants, including stress tolerance, are complex traits controlled by quantitative trait loci (QTLs). Isolation of these QTLs holds great promise to improve world agricul...

    Zhong-Hai Ren, Ji-** Gao, Le-Gong Li, **u-Ling Cai, Wei Huang in Nature Genetics (2005)

  15. No Access

    Article

    Genetic and physical map** of Pi36(t), a novel rice blast resistance gene located on rice chromosome 8

    Blast resistance in the indica cultivar (cv.) Q61 was inherited as a single dominant gene in two F2 populations, F2-1 and F2-2, derived from crosses between the donor cv. and two susceptible japonica cvs. Aichi A...

    X. Q. Liu, L. Wang, S. Chen, F. Lin, Q. H. Pan in Molecular Genetics and Genomics (2005)

  16. No Access

    Article

    The Mutually Exclusive Flip and Flop Exons of AMPA Receptor Genes Were Derived from an Intragenic Duplication in the Vertebrate Lineage

    The incomplete correlation between the organismal complexities and the number of genes among eukaryotic organisms can be partially explained by multiple protein products of a gene created by alternative splici...

    Yu-Chia Chen, Wei-Hsiang Lin, Der-Wang Tzeng in Journal of Molecular Evolution (2006)

  17. Article

    Open Access

    Analysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system

    The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones. Towards a better ...

    Wei-Hua Chen, Xue-**a Wang, Wei Lin, **ao-Wei He, Zhen-Qiang Wu, Ying Lin in BMC Genomics (2006)

  18. No Access

    Article

    RAPD analysis of genetic diversity and population genetic structure of Stipa krylovii reshov. in Inner Mongolia steppe

    Random amplified polymorphic DNA (RAPD) analysis was used to characterize the genetic diversity and population genetic structure of Stipa krylovii populations in Inner Mongolia steppe of North China. Thirteen 10-...

    J. L. Wang, N. X. Zhao, Y. B. Gai, F. Lin, A. Z. Ren in Russian Journal of Genetics (2006)

  19. No Access

    Article

    A new cell line from larval fat bodies of the bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)

    A new cell line, designated IOZCAS-Ha-I, was initiated from the fat body of larvae of Helicoverpa armigera (Lepidoptera: Noctuidae) in TNM-FH medium containing 10% fetal bovine serum. Spherical cells were predomi...

    Huan Zhang, Yong-An Zhang, Qilian Qin in In Vitro Cellular & Developmental Biology … (2006)

  20. Article

    Open Access

    Identification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research

    An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...

    Yang Wang, Tingting Weng, Deming Gou, Zhongming Chen in BMC Genomics (2007)

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