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  1. No Access

    Article

    An immunohistochemical and ultrastructural study of a follicle-stimulating hormone-secreting gonadotroph adenoma occurring in a 10-year-old girl

    Female gonadotroph adenomas with endocrinological symptoms are uncommon. Six cases of such adenomas have been reported in the literature: two were girls who presented with precocious puberty and four were pre...

    H. Tashiro, H. Katabuchi, H. Ohtake, A. Yoshioka… in Medical Electron Microscopy (2000)

  2. No Access

    Chapter

    Kynurenine Concentration of Serum Was Increased by Exercise

    Kynurenine pathway of tryptophan makes a lot of physiological active substances, such as quinolinate, NAD and so on, suggesting that kynurenine itself may play a very important role physiologically.

    Y. Ito, K. Saito, K. Maruta, Y. Nakagami, T. Koike… in Tryptophan, Serotonin, and Melatonin (1999)

  3. No Access

    Chapter

    Ommochrome Genesis in an Albino Strain of a Terrestrial Isopod

    The contents of tryptophan (Trp) metabolites and the activities of the enzymes involved in ommochrome biosynthesis were measured in an albino strain of a terrestrial isopod Armadillidium vulgare. There was little...

    Y. Hasegawa, S. Negishi, J. Naito, R. Ikeda… in Tryptophan, Serotonin, and Melatonin (1999)

  4. No Access

    Chapter

    Cinnabarinic Acid was Formed in Damaged Mitochondria and its Effect on Mitochondrial Respiration

    Tryptophan administration aggravates experimental mouse liver injury caused by carbon tetrachloride when 3-hydroxyanthranilic acid concentration elevates in serum. Tryptophan metabolism is changed by macrophag...

    Y. Nagamura, K. Uesugi, J. Naito, I. Ishiguro in Tryptophan, Serotonin, and Melatonin (1999)

  5. No Access

    Chapter

    Involvement of Tryptophan Metabolism in the Body Color of Crustacea

    The terrestrial isopod, Armadillidium vulgare is usually grey or black in color, however, red ones are occasionally found in the field. This is caused by the mutation of the ommochrome genesis in the integument. ...

    S. Negishi, Y. Hasegawa, J. Naito, Y. Nagamura… in Tryptophan, Serotonin, and Melatonin (1999)

  6. No Access

    Article

    Identification of quantitative trait loci controlling heading date in rice using a high-density linkage map

     Quantitative trait locus (QTL) analysis has been carried out to identify genes conferring heading date in rice. One hundred and eighty six F2 plants derived from a cross between a japonica variety, Nipponbare, a...

    M. Yano, Y. Harushima, Y. Nagamura, N. Kurata… in Theoretical and Applied Genetics (1997)

  7. No Access

    Chapter and Conference Paper

    Early Detection of Successful Coronary Reperfusion Based on Serum Levels of Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein

    Heart-type cytoplasmic fatty acid-binding protein (H-FABPc) is a cytoplasmic low molecular weight protein similar to myoglobin. The skeletal myoglobin content is approximately twice that of the heart, while th...

    J. Ishii, Y. Nagamura, N. Masanori, Y. Watanabe… in Advances in Critical Care Testing (1997)

  8. No Access

    Article

    Identification of a YAC clone carrying the Xa-1 allele, a bacterial blight resistance gene in rice

    Map-based cloning methods have been applied for isolation of Xa-1, one of the bacterial blight resistance genes in rice.Xa-1 was previously mapped on chromosome 4 using molecular markers. For positional cloning o...

    S. Yoshimura, Y. Umehara, N. Kurata, Y. Nagamura… in Theoretical and Applied Genetics (1996)

  9. No Access

    Article

    Detection of segregation distortions in an indica-japonica rice cross using a high-resolution molecular map

    We have constructed a high-resolution rice genetic map containing 1383 DNA markers covering 1575 cM on the 12 linkage groups of rice using 186 F2 progeny from a cross between a japonica variety, ‘Nipponbare’, and...

    Y. Harushima, N. Kurata, M. Yano, Y. Nagamura… in Theoretical and Applied Genetics (1996)

  10. No Access

    Chapter

    Macrophages Modulate Liver Cell Function via Tryptophan Metabolites

    We have reported that administration of tryptophan (Trp) usually cures hepatic injury caused by carbontetrachrolide but occasionally causes aggravation of it and the serum concentration of kynurenine (Kyn) in ...

    Y. Nagamura, K. Uesugi, J. Naito, K. Saitoh… in Recent Advances in Tryptophan Research (1996)

  11. No Access

    Chapter

    Kynurenine Pathway Metabolism in the Galactosamine Model of Hepatic Injury

    The mechanisms involved in producing hepatic encephalopathy and hepatic coma are unclear, but include an accumulation of neurotoxic metabolites. Elevated plasma concentrations of aromatic amino acids, includin...

    K. Saito, M. Seishima, A. Noma, Y. Nagamura… in Recent Advances in Tryptophan Research (1996)

  12. No Access

    Article

    Linkage localization of the starch branching enzyme I (Q-enzyme I) gene in rice

    Y. Nakamura, Y. Nagamura, N. Kurata, Y. Minobe in Theoretical and Applied Genetics (1994)

  13. No Access

    Article

    A 300 kilobase interval genetic map of rice including 883 expressed sequences

    We have constructed a high resolution rice genetic map containing 1,383 DNA markers at an average interval of 300 kilobases (kb). The markers, distributed along 1,575 cM on 12 linkage groups, comprise 883 cDNA...

    N. Kurata, Y. Nagamura, K. Yamamoto, Y. Harushima, N. Sue, J. Wu… in Nature Genetics (1994)

  14. No Access

    Article

    Sequence-tagged sites (STSs) as standard landmarkers in the rice genome

    Generating sequence-tagged sites (STSs) is a prerequisite to convert a genetic map to a physical map. With the help of sequence information from these STSs one can also isolate specific genes. For these purpos...

    T. Inoue, H. S. Zhong, A. Miyao, I. Ashikawa, L. Monna… in Theoretical and Applied Genetics (1994)

  15. No Access

    Chapter

    Rat Skin Tryptophan 2,3-Dioxygenase

    The fact that a considerable amount of kynurenine (Kyn) is species-specifically accumulated in rat fur was discovered in 1960 by Ishiguro and co-workers (Hotta et al., 1960). The cause of this phenomenon has b...

    J. Naito, I. Ishiguro, Y. Nagamura, H. Ogawa in Kynurenine and Serotonin Pathways (1991)

  16. No Access

    Chapter

    Specific Binding of L-Tryptophan to Serum Albumin and its Function in Vivo

    Many kinds of organic anions such as long-fatty acids, bilirubin, bile acids and hormones, bind to albumin in the plasma. L-Tryptophan (Trp) also binds to albumin in the plasma, and this property is quite diff...

    E. Sasaki, K. Saito, Y. Ohta, I. Ishiguro, Y. Nagamura… in Kynurenine and Serotonin Pathways (1991)

  17. No Access

    Chapter

    Characterization of L-Tryptophan Transport into Liver in Suckling Rats

    In adult rats, about 10% of total plasma L-tryptophan (Trp) (ca. 100 μM) exists in a free form (not albumin-bound) under physiological conditions (Madras et al., 1974). We have demonstrated that Trp uptake int...

    K. Saito, Y. Nagamura, Y. Ohta, E. Sasaki, I. Ishiguro in Kynurenine and Serotonin Pathways (1991)

  18. No Access

    Chapter and Conference Paper

    Diabetologie

    Wir versuchten in vivo, ob Insulin eine negative Rückkopplung auf seine eigene Sekretion ausübt. Zur Klärung der physiologischen Bedeutung eines derartigen Feedbacks wurden gesunde ideal- bis normalgewichtige ...

    W. Beischer, W. Kerner, M. Schmid… in Verhandlungen der Deutschen Gesellschaft f… (1982)

  19. No Access

    Article

    Enzymatic hydroxylation of anthranilamide in rat liver

    Das als Anthranilamid-5-Hydroxylase bezeichnete Enzym, das von Anthranilamid zu 5-OH-Anthranilamid hydroxyliert wird, wurde in den Mikrosomen von Rattenleberzellen lokalisiert.

    T. M. Sutamihardja, A. Ishikura, Y. Nagamura, I. Ishiguro in Experientia (1973)