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Article
Dense genoty** of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathwa...
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Chapter
Genomics and Viruses in Sjögren’s Syndrome
Contributions from both genetic and environmental factors to the etiology of Sjögren’s syndrome (SS) are being discovered, though their roles in disease pathogenesis remain obscure. An important key to fully u...
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Chapter
Genetics, Genomics, and Proteomics of Sjögren’s Syndrome
Dramatic advances in identifying the genetic basis of many human diseases are transforming our fundamental understanding of etiology and pathogenesis. Over the past decade, large global efforts to characterize...
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Article
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Patrick Gaffney and colleagues perform a fine-map** study of the TNFAIP3 region in systemic lupus erythematosus using individuals from diverse ancestral populations. They identify a putative causal variant in a...
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Article
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Patrick Gaffney and colleagues report results of a genome-wide association study for systemic lupus erythematosus (SLE), identifying variants in the TNFAIP3 region on 6q23 that are strongly associated with the di...
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Article
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (λS = ∼30). We performed a genome-wide association scan using 317,501 SNPs in 720...
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Article
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE susceptibility has been established1,2,3. Recent su...
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Article
An ensemble method for gene discovery based on DNA microarray data
The advent of DNA microarray technology has offered the promise of casting new insights onto deciphering secrets of life by monitoring activities of thousands of genes simultaneously. Current analyses of micro...
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Article
Open AccessMultivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches
Current statistical methods for sib-pair linkage analysis of complex diseases include linear models, generalized linear models, and novel data mining techniques. The purpose of this study was to further invest...
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Article
Open AccessGenetic linkage analysis of longitudinal hypertension phenotypes using three summary measures
Longitudinal data often have multiple (repeated) measures recorded along a time trajectory. For example, the two cohorts from the Framingham Heart Study (GAW13 Problem 1) contain 21 and 5 repeated measures for...
