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Article
Open AccessEpidemiology and Early Bacteriology of Extremely Severe Burns from an LPG Tanker Explosion in Eastern China
The incidence of liquefied petroleum gas (LPG)-related accidents in China has increased over the recent years. In addition, infection remains a big challenge in cases of severe burns. Therefore, the present st...
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Article
Open AccessRegeneration of skin appendages and nerves: current status and further challenges
Tissue-engineered skin (TES), as an analogue of native skin, is promising for wound repair and regeneration. However, a major drawback of TES products is a lack of skin appendages and nerves to enhance skin he...
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Article
Open AccessNon-viral gene delivery systems for tissue repair and regeneration
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE)...
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Article
Open AccessErythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response is unknown. We report that in healthy lowlanders, plasma adenosine lev...
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Article
Open AccessComputational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor
GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development a...
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Article
Open AccessThe role of pleiotrophin and β-catenin in fetal lung development
Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins. Abnormal changes of these molecules often...
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Article
Open AccessArsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis
Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the mo...
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Article
Open AccessIdentification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research
An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...
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Article
Open AccessIdentification of rat lung – prominent genes by a parallel DNA microarray hybridization
The comparison of organ transcriptomes is an important strategy for understanding gene functions. In the present study, we attempted to identify lung-prominent genes by comparing the normal transcriptomes of r...
