36 Result(s)

Article

Map** crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq

Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual dip...

Yan Wang, Yijun Chen, Junpeng Gao, Haoling **e, Yuqing Guo, **gwei Yang… in Cell Discovery (2024)

Article

Deciphering the role of immunoglobulin secreting malignant lineages in the invasive frontiers of small cell lung cancer by scRNA-seq and spatial transcriptomics analysis

Fei Wu, **ao Zhang, Minglei Wang, **gxin Zhang, Minxin Chen, Ziyuan Ren… in Cell Discovery (2023)

Article

Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487

Haizhan Jiao, Bin Pang, Ying-Chih Chiang, Qiang Chen, Qi Pan, Ruobing Ren… in Cell Discovery (2023)

Article

Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 receptor

Yaning Li, Chang Ren, Ya** Shen, Yuanyuan Zhang, ** Chen… in Cell Discovery (2023)

Article

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desu...

Jialun Li, Lu Lu, Lingling Liu, Xuelian Ren, Jiwei Chen, **ngzhi Yin… in Cell Discovery (2023)

Article

The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth

IscU2 is a scaffold protein that is critical for the assembly of iron–sulfur (Fe–S) clusters and the functions of Fe–S-containing mitochondrial proteins. However, the role of IscU2 in tumor development remains...

**aojun Ren, Jimei Yan, Qiongya Zhao, **nzhu Bao, **nyu Han, Chen Zheng… in Cell Discovery (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

Originally discovered in the circulation of pregnant women as a protein secreted by placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP-A) is also widely expressed by many o...

Qihang Zhong, Honglei Chu, Guopeng Wang, Cheng Zhang, Rong Li… in Cell Discovery (2022)

Article

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6

Aiste Dijokaite-Guraliuc, Raksha Das, Rungtiwa Nutalai, Daming Zhou… in Cell Discovery (2022)

Article

Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum

Jiandong Huo, Aiste Dijokaite-Guraliuc, Rungtiwa Nutalai, Raksha Das… in Cell Discovery (2022)

Article

Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma

Gallbladder carcinoma (GBC) is the most common biliary tract malignancy with the lowest survival rate, primarily arising from chronic inflammation. To better characterize the progression from inflammation to c...

**ang Wang, Chunliang Liu, Jianan Chen, Lei Chen, **anwen Ren… in Cell Discovery (2022)

Article

RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models

The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide, leading to the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have been demonstrated to regulate life cycl...

Geng Qin, Chuanqi Zhao, Yan Liu, Cheng Zhang, Guang Yang, Jie Yang… in Cell Discovery (2022)

Article

A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype

Cardiac fibrosis is associated with activation of cardiac fibroblasts (CFs), a pathological, phenotypic transition that is widely believed to be irreversible in the late stages of disease development. Sensing ...

Lele Niu, Bo Cheng, Guoyou Huang, Kai Nan, Shuang Han, Hui Ren, Na Liu… in Cell Discovery (2022)

Article

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

Zhenhao Fang, Lei Peng, Carolina Lucas, Qianqian Lin, Liqun Zhou… in Cell Discovery (2022)

Article

Cell-in-cell structure mediates in-cell killing suppressed by CD44

Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led t...

Yan Su, Hongyan Huang, Tianzhi Luo, You Zheng, Jie Fan, He Ren, Meng Tang… in Cell Discovery (2022)

Article

Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2

The continuous emergence of SARS-CoV-2 variants highlights the need of develo** vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representativ...

Yu Liang, **g Zhang, Run Yu Yuan, Mei Yu Wang, Peng He, Ji Guo Su… in Cell Discovery (2022)

Article

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Safe, effective, and economical vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to achieve adequate herd immunity and end the pandemic. We constructed a novel SARS-CoV-...

Yiru Long, Jianhua Sun, Tian-Zhang Song, Tingting Liu, Feng Tang… in Cell Discovery (2022)

Article

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether suc...

Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang, Yang Yu… in Cell Discovery (2022)

Article

Author Correction: Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu, Hai-mei Li, Hao Yu, Yan Liu, Chen-**ng Liu, **an-bo Zuo… in Cell Discovery (2021)

Article

Establishment of human distal lung organoids for SARS-CoV-2 infection

Ting Wang, Ning Zhang, Shipan Fan, Lianzheng Zhao, Wanlu Song… in Cell Discovery (2021)