14 Result(s)

Article

Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy

COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g. casirivimab+i...

Manon Ragonnet-Cronin, Rungtiwa Nutalai, Jiandong Huo… in Nature Communications (2023)

Article

Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5, BQ.1, BQ.1.1, BF.7 and BA.2.75.2

Airu Zhu, Peilan Wei, Miao Man, Xuesong Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6

Aiste Dijokaite-Guraliuc, Raksha Das, Rungtiwa Nutalai, Daming Zhou… in Cell Discovery (2022)

Article

Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum

Jiandong Huo, Aiste Dijokaite-Guraliuc, Rungtiwa Nutalai, Raksha Das… in Cell Discovery (2022)

Article

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80 and C...

Alan Kennedy, Erin Waters, Behzad Rowshanravan, Claudia Hinze… in Nature Immunology (2022)

Article

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanob...

Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark… in Nature Communications (2021)

Article

A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, and for seeking evidence for a level of antibody that may be protective against COVID-19 ...

Alain Townsend, Pramila Rijal, Julie **ao, Tiong Kit Tan… in Nature Communications (2021)

Article

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

A Correction to this paper has been published: https://doi.org/10.1038/s41594-021-00566-w.

Jiandong Huo, Audrey Le Bas, Reinis R. Ruza… in Nature Structural & Molecular Biology (2021)

Article

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the ...

Tiong Kit Tan, Pramila Rijal, Rolle Rahikainen, Anthony H. Keeble… in Nature Communications (2021)

Article

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A, from an individual convalescing from COVID-19 and ha...

Daming Zhou, Helen M. E. Duyvesteyn… in Nature Structural & Molecular Biology (2020)

Article

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human ang...

Jiandong Huo, Audrey Le Bas, Reinis R. Ruza… in Nature Structural & Molecular Biology (2020)

Article

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 foll...

Simon P. Graham, Rebecca K. McLean, Alexandra J. Spencer… in npj Vaccines (2020)