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  1. No Access

    Chapter and Conference Paper

    The Structure and Evolution of Transplantation Antigens

    Our laboratory has been interested for the past ten years in the strategies complex multigenic families, such as antibodies, employed for dealing with extremely large amounts of information (Hood and Prahl, 19...

    L. Hood, J. Silver in The Immune System (1976)

  2. No Access

    Chapter and Conference Paper

    Clonal Selection and Network Regulation

    This article will be concerned with the process of diversification during the ontogenic development of the immune system. We shall advance the thesis that diversification is not only a problem of the phylogene...

    E. Weiler, G. Adam, W. Schuler, I. J. Weiler in The Immune System (1976)

  3. No Access

    Chapter and Conference Paper

    Role of Serum Lipoproteins in the Transport of Cellular Cholesterol

    The subject of this presentation is the role of serum lipoproteins in the transport of cellular cholesterol. The donors of cellular cholesterol originate mostly in the liver and the pathways of their synthesis...

    Y. Stein, O. Stein, J. Vanderhoek in Lipoprotein Metabolism (1976)

  4. No Access

    Chapter and Conference Paper

    Immune Response Region Associated (Ia) Antigens. Some Structural Features

    Ia antigens form an integral part of the lymphocyte cell membrane, and are direct gene products of the I- or Immune Response Region of the Major Histocompatibility Complex (MHC) of the mouse. Twenty one serologic...

    M. Hess in The Immune System (1976)

  5. No Access

    Chapter and Conference Paper

    Two Immunological Worlds: Antibody Molecules and Lymphoid Cell-Surfaces. An Overview of the Mosbach Colloquium

    My assignment in this meeting is to summarize the proceedings of the past two days. Most of the talks were themselves summaries. To compress them further might well result in gibberish. Nevertheless, I intend ...

    H. N. Eisen in The Immune System (1976)

  6. No Access

    Chapter and Conference Paper

    Effects of Low Dose Phytosterols on Cholesterol Absorption in Man

    The plasma cholesterol lowering action of phytosterols has been known for many years (1 – 3). It has generally been thought that large doses of phytosterols are required to obtain a significant reduction in pl...

    S. M. Grundy, H. Y. I. Mok in Lipoprotein Metabolism (1976)

  7. No Access

    Chapter and Conference Paper

    Sitosterol in Type II Hyperlipoproteinemia

    In 1951, PETERSON reported that the increase of plasma cholesterol levels in chickens caused by cholesterol feeding can be prevented by including 1 % soybean sterols in the diet (18). Since then, numerous inve...

    P. Oster, G. Schlierf, C. Heuck, H. Greten, U. Gundert-Remy… in Lipoprotein Metabolism (1976)

  8. No Access

    Chapter and Conference Paper

    Human Postheparin Plasma Lipolytic Activities

    Human postheparin lipolytic activities (PHLA) are considered to bemajor factors in the removal of triglycerides from circulating plasma lipoproteins (1). It was assumed, that this glycerol ester hydrolase acti...

    J. Augustin, H. Freeze, J. Boberg, W. V. Brown in Lipoprotein Metabolism (1976)

  9. No Access

    Chapter and Conference Paper

    Molecular Association of Lipids and Proteins in the Plasma Lipoproteins: A Review

    In blood, the plasma lipoproteins represent the major vehicle for the transport of triglyceride, cholesterol, both free and esterified, and phospholipid. In addition, these macromolecular complexes are also su...

    A. M. Gotto, R. L. Jackson Jr., J. D. Morrisett, H. J. Pownall… in Lipoprotein Metabolism (1976)

  10. No Access

    Chapter and Conference Paper

    Reversible Activation-Deactivation of Hormone-Sensitive Lipase and Observations on its Relation to Lipoprotein Lipase

    The rate of release of free fatty acids (FFA) from adipose tissue is stimulated by catecholamines, glucagon, ACTH, and many other so-called lipolytic hormones.The increase in FFA release from intact tissue cor...

    D. Steinberg, J. C. Khoo in Lipoprotein Metabolism (1976)

  11. No Access

    Chapter and Conference Paper

    Structure and Specificity of Immunoglobulins

    In this presentation we will briefly review our results on the study of the amino acid sequence and the three-dimensional structure of the Fab fragment from a human myeloma protein, IgG1 New (λ, Gm 1+, 3-, 4-,...

    R. J. Poljak, L. M. Amzel, B. L. Chen, Y. Y. Chiu, R. P. Phizackerley… in The Immune System (1976)

  12. No Access

    Chapter and Conference Paper

    Metabolism of Very Low Density Lipoproteins

    The plasma lipoprotein system is traditionally separated into several lipoprotein families defined by physical, chemical, and immunochemical methods. Yet, during the last few years, it has been shown that all ...

    S. Eisenberg in Lipoprotein Metabolism (1976)

  13. No Access

    Chapter and Conference Paper

    Recognition and Allostery in the Mechanism of Antibody Action

    The binding equilibria of antibody and hapten are usually characterized by a single step mechanism. This simple mechanism enabled the detailed analysis of molecular recognition in kinetic terms. Still this mec...

    I. Pecht in The Immune System (1976)

  14. No Access

    Chapter and Conference Paper

    The Composition, Structure, and Metabolism of High Density Lipoprotein

    The purpose of this report is to review recent advances in the understanding of high density lipoprotein (HDL) composition, structure, and metabolism. HDL appears to serve as a carrier for cholesterol, mainly ...

    R. I. Levy, C. B. Blum, E. J. Schaefer in Lipoprotein Metabolism (1976)

  15. No Access

    Chapter and Conference Paper

    Genetic Control of T and B Cell Receptor Specificity in the Mouse

    The function of the immune system is based on a large variety of receptor molecules whose combining sites can recognize virtually every antigenic substance in the universe. This capacity is reflected in a pron...

    K. Eichmann, C. Berek, G. Hämmerling, S. Black, K. Rajewsky in The Immune System (1976)

  16. No Access

    Chapter and Conference Paper

    Differentiation of Immunoglobulin Genes

    Recent advances in the technology of nucleic acid biochemistry, in particular the availability of highly purified, light and heavy chain mRNAs from mouse plasmacytomas, have enabled several groups of researche...

    S. Tonegawa, N. Hozumi in The Immune System (1976)

  17. No Access

    Chapter and Conference Paper

    Characteristics of B Lymphocytes and Their Mechanism of Activation

    The function of the lymphoid system is to defend the individual against otherwise lethal microbial infections. Although the important cells in the system — the small lymphocytes — are all morphologically simil...

    G. Möller in The Immune System (1976)

  18. No Access

    Chapter and Conference Paper

    Tumors of Immunoglobulin-Producing Cells and Thymus-Derived Lymphocytes

    The immunoglobulin-producing cells differentiate so that one specialized cell and its progeny by mitosis are limited to produce immunoglobulin molecules with a single binding specificity. The binding specifici...

    M. Potter in The Immune System (1976)

  19. No Access

    Chapter and Conference Paper

    The Major Histocompatibility Complex and Its Biological Function

    It was one of the very early findings in transplantation research that the survival of grafted organs was largely dependent on the degree of genetic similarity between donor and recipient. Selective breeding i...

    E. D. Albert in The Immune System (1976)

  20. No Access

    Chapter and Conference Paper

    Lipid Composition of the Major Human Serum Lipoprotein Density Classes in Different Types of Hyperlipoproteinemia

    The six types of hyperlipoproteinemia recognized in the WHO memorandum (1) are based upon criteria that take into consideration the concentration of very low density (VLDL) and low density (LDL) lipoproteins.T...

    L. A. Carlson in Lipoprotein Metabolism (1976)

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