6 Result(s)
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Chapter
Chromosomal Analysis of Spontaneous Hepatomas, a Derived Cell Line, and Chemically Induced Hepatomas in LEC Rats
Recent banding studies of chromosomes in a variety of human and animal tumors have provided a growing body of evidence that certain specific or nonrandom chromosomal changes are causally related to or closely ...
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Chapter
Hepatoma-Associated Alterations of Serum α1-Antitrypsin in LEC Rats
LEC rats have been established as a new mutant strain which develops hereditary hepatitis [1–3] and spontaneous hepatocellular carcinomas (hepatomas) [4]. However, the mechanisms of the development of the sequ...
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Chapter
Chromosomal Map** of the Placental Glutathione S-Transferase Gene and Its Expression in Livers of LEC Rats
The LEC strain rat is a new mutant which suddenly suffers from fulminant hepatitis at about 4 months of age [1, 2]. A crossing test of LEC rats showed that the hepatitis has an autosomal recessive mode of inhe...
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Chapter
High Susceptibility to Spontaneous Development of Hepatocellular Carcinoma in LEC Rats
Spontaneous hepatitis was first found in the LEC strain rat, which had been maintained conventionally at the Center for Experimental Plants and Animals, Hokkaido University [1]. The hepatitis appears suddenly ...
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Chapter
Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide
The LEC rat strain is a new mutant characterized by the spontaneous development of hepatitis with severe jaundice about 4 months of age [1, 2]. Genetic analysis demonstrated that the disease has an autosomal r...
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Chapter
Origin of the LEC Strain with a New Mutation Causing Hereditary Hepatitis
Over the last 10 years, a large number of animal models for human diseases has been discovered in laboratory mice and rats. Such model animals have become an indispensable tool in many fields of biological and...
