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    Chapter

    Gene Therapy for Coronary Artery Disease

    Congestive heart failure is the common end point for advanced coronary artery disease and the leading cause of mortality from heart disease. Stents and surgical bypass can address focal obstruction in larger c...

    Vivekkumar B. Patel, Christopher T. Ryan, Ronald G. Crystal… in Cardiac Surgery (2020)

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    Chapter

    Genetic Evaluation of Male Infertility

    Male infertility affects 7% of all men worldwide, yet for the majority the underlying cause is not found. From the very first identified karyoty** abnormalities to the very recent discovery of point mutation...

    Khalid A. Fakhro, Amal Robay, Juan L. Rodriguez-Flores… in Genetics of Male Infertility (2020)

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    Chapter

    Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders

    Addictive drugs are a major worldwide problem, and for many there are few effective therapies. Based on the concept that high titers of drug-specific antibodies can bind to addictive drugs in the blood prevent...

    David F. Havlicek, Jonathan B. Rosenberg… in Biologics to Treat Substance Use Disorders (2016)

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    Chapter

    Setting Back the Clock: Adenoviral-Mediated Gene Therapy for Lysosomal Storage Disorders

    Lysosomal storage diseases (LSD) arise from mutations in the genes for lysosomal proteins that degrade and recycle macromolecules (Futerman and van Meer, 2004; Mach, 2002; Vellodi, 2005; Walkley, 2001). The un...

    Dolan Sondhi, Neil R. Hackett, Stephen M. Kaminksy… in Lysosomal Storage Disorders (2007)

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    Chapter

    Cancer-Related Gene Therapy Clinical Trials

    Gene therapy represents a strategy using transfer of genetic information to modify a population of target cells for therapeutic purposes. The transferred genetic material has typically included double-stranded...

    Robert J. Korst, Ronald G. Crystal in Cancer Gene Therapy (2005)

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    Chapter

    Myocardial Angiogenesis: Biology and Therapy

    Despite significant advances in its prevention and treatment, coronary artery disease (CAD) remains the leading cause of death in the Western world today. The economic burden of CAD on society is significant. ...

    Charles A. Mack, Shailen R. Patel… in Direct Myocardial Revascularization: Histo… (1999)

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    Chapter

    Evaluation of Inflammatory and Immune Processes in the Interstitial Lung Disorders: Use of Bronchoalveolar Lavage

    The interstitial lung diseases are a group of chronic, usually fatal disorders that diffusively involve the alveolar structures.1–9 Although there are many types of interstitial diseases, all are characterized by...

    Giovanni A. Rossi, Gary W. Hunninghake, Ronald G. Crystal in Cellular Biology of the Lung (1982)