-
Article
Open Accessp63 silencing induces epigenetic modulation to enhance human cardiac fibroblast to cardiomyocyte-like differentiation
Direct cell reprogramming represents a promising new myocardial regeneration strategy involving in situ transdifferentiation of cardiac fibroblasts into induced cardiomyocytes. Adult human cells are relatively...
-
Article
Open AccessFibroblast transition to an endothelial “trans” state improves cell reprogramming efficiency
Fibroblast reprogramming offers the potential for myocardial regeneration via in situ cell transdifferentiation. We explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming eff...
-
Chapter
Gene Therapy for Coronary Artery Disease
Congestive heart failure is the common end point for advanced coronary artery disease and the leading cause of mortality from heart disease. Stents and surgical bypass can address focal obstruction in larger c...
