6 Result(s)
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Jonathan B. Rosenberg
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Article
Open AccessExpression and processing of mature human frataxin after gene therapy in mice
Friedreich’s ataxia is a degenerative and progressive multisystem disorder caused by mutations in the highly conserved frataxin (FXN) gene that results in FXN protein deficiency and mitochondrial dysfunction. ...
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Chapter
Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders
Addictive drugs are a major worldwide problem, and for many there are few effective therapies. Based on the concept that high titers of drug-specific antibodies can bind to addictive drugs in the blood prevent...
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Article
Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter
Cocaine addiction is a major problem for which there is no approved pharmacotherapy. We have developed a vaccine to cocaine (dAd5GNE), based on the cocaine analog GNE linked to the capsid proteins of a serotyp...
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Article
Novel Cocaine Vaccine Linked to a Disrupted Adenovirus Gene Transfer Vector Blocks Cocaine Psychostimulant and Reinforcing Effects
Immunotherapy is a promising treatment for drug addiction. However, insufficient immune responses to vaccines in most subjects pose a challenge. In this study, we tested the efficacy of a new cocaine vaccine (...
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Article
Creating a DDAVP Releasable Pool of Factor VIII: Its Impact on the Gene Therapy of Hemophilia A † 786
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Chapter
CAD Tools for Mask Generation
CAD Tools for Mask Generation is a general title that refers to Computer-Aided Design software that produces as its output mask-level descriptions of integrated circuits. The current state-of-the-art for general ...
