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Chapter and Conference Paper
In Vitro Sensitivity to Chemotherapy-Induced Apoptosis in CD2+ve and CD2-ve Childhood T-All
T-lineage acute lymphoblastic leukemia (T- ALL) account for approximately 15% of all childhood acute leukemias and has been reported to have a worse prognosis than B- lineage ALL (Reiter et al., 1994; Uckun et...
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Chapter and Conference Paper
Involvement of BCL-2 and Bax in the IL-7-lnduced Inhibition of Spontaneous Apoptosis in Childhood T-ALL
Induction of apoptosis by cytokine deprivation and its inhibition by cytokines in growth factor-dependent cell lines has been demonstrated to be under the control of Bcl-2-related proteins. Recently, we have d...
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Chapter and Conference Paper
CD95-Mediated Apoptosis in Acute Myeloid Leukemia (AML): Dependence on Maturational Stage and Growth Characteristics in Vitro
The CD95 (APO-1/Fas) receptor, which is able to induce apoptotic cell death upon oligomerization by its natural ligand or by anti-CD95 antibodies, is broadly distributed in normal and malignant hematopoietic c...
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Chapter and Conference Paper
Untersuchungen zur Mastzellbiologie mittels monoklonaler Antikörper
Trotz einer steigenden Zahl von Arbeiten zu Fragen der Mastzelldifferenzierung ist der genaue Differenzierungsweg der Mastzellen noch immer unklar. Ziel dieser Arbeit war daher, durch Erzeugung monoklonaler An...
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Chapter and Conference Paper
Herstellung und Nutzung bispezifischer monoklonaler Antikörper
Die unter natürlichen Bedingungen produzierten Antikörper sind in ihrer Grundstruktur monospezifisch, d.h. alle Antigenbindungsorte des Antikörpermoleküls sind identisch. Die praktische Nutzung von Antikörpern...
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Chapter and Conference Paper
Use of Fluorescence-Activated Cell Sorting to Select Hybrid Hybridomas Producing Bispecific Monoclonal Antibodies
Antibodies containing two different antigenbinding sites were prepared for the first time in 1961 by Nisonoff and Rivers [1] by dissociating two different antibodies and reassociating the mixture of half molec...
