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Chapter and Conference Paper
A New Particle is Suggested by Anomalies Observed in Internal e \( ^+ \) e \( ^- \) Pair Creation
Several years ago, we detected unusual electron-positron angular correlations in the 18.15 MeV M1 transition of \(^8\) ...
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Chapter
Understanding Melanoma Progression by Gene Expression Signatures
Malignant melanoma is the most aggressive cancer in humans and understanding this unique biological behavior may help to design better prognosticators and more efficient therapies. However, malignant melanoma ...
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Chapter and Conference Paper
Probing shell structure in neutron-rich nuclei with in-beam γ-spectroscopy
The structure of neutron-rich light nuclei around N = 20 and 28 has been investigated at GANIL by means of in-beam gamma-spectroscopy using fragmentation reactions of 36S and 48Ca beams on a Be target. Gamma-deca...
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Chapter and Conference Paper
Gamma spectroscopy of the last bound oxygen isotopes
γ transitions were measured in coincidence with very neutron rich fragments around Z = 8 produced by the fragmentation of a secondary beam.
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Chapter
Lifetime Measurements and Dipole Transition Rates for Superdeformed States in 190Hg
The Doppler-shift attenuation method was used to measure lifetimes of superdeformed (SD) states for both the yrast and the first excited superdeformed band of 190Hg. Intrinsic quadrupole moments Q o
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Chapter
12-Lipoxygenase Expression in Human Melanoma Cell Lines
12-lipoxygenase (12-LOX) expression and function in the regulation of the metastatic phenotype was demonstrated in several murine melanoma lines before. Here we have provided novel evidences that, though at a ...
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Chapter
Systematics of Terminating Configurations in A ≈100 Pd Nuclei
High-spin states of 100–103Pd have been studied using high-fold γ-ray coincidence data obtained with the EUROGAM-2 spectrometer and the 70Zn(36S,xn) reaction at E=130 MeV. New high-spin bands were found and the p...
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Chapter
12-(S)-HETE Induces Cytoskeleton Phosphorylations and Rearrangement in Melanoma Cells
Lipoxygenase metabolites of arachidonic acid (AA) are responsible for alterations in membrane receptor expression, regulated secretion of cellular products as well as in cell motility (1). These alterations in...
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Chapter
Effect of 12-HETE on the Expression of Autocrine Motility Factor-Receptor and Motility in Melanoma Cells
A 12-lipoxygenase metabolite of archidonic acid, 12-(S)-hydroxyglicosatetraenoic acid (12-(S)- HETE), which is synthesized by cancer cells was tested for its ability to affect the motility of K-1735 murine mel...
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Chapter
Activation Of Protein Kinase C by 12(S)-HETE: Role in Tumor Cell Metastasis
Protein kinase C (PKC), the Ca2+ and phospholipid dependent kinase, belongs to the family of protein serine/threorine kinases (1). It is an important enzyme in mediating cell growth, cell differentiation and tumo...
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Chapter
Fatty Acid Modulation of Cancer Cell Spreading and Cytoskeleton Rearrangement
Tumor cell — extracellular matrix interactions consist of attachment, spreading, migration and digestion of matrix ligands. These interactions are critical determinants during metastasis (1,2) and are mediated...
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Chapter
The Lipoxygenase Metabolite of Arachidonic Acid, 12-(S)-Hete, Induces Cytoskeleton Dependent Upregulation of Integrin αIIbβ3 in Melanoma Cells
Cell-extracellular matrix interactions are essential prerequisites of normal cell function mediated by specific receptors including integrins (1). This family of transmembrane proteins are characterized by α a...
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Chapter
Differences in Cell Surface Characteristics of Poorly and Highly Metastatic Lewis Lung Tumor Variants
The acquisition of invasive and metastatic phenotypes in a transformed cell population is the key event in tumor development and progression. The animal and human neoplasms are characterized by a wide diversit...
