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Classifications of Definable Subsets
Given a structure ℳ over ω and a syntactic complexity class E\( \mathfrak{E} \), we say that a subset is E\( \mathfrak{E} \)-definable in ℳ if there exists a C-formula Θ(x) in the language of ℳ such that for all
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Open AccessInhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors
Anaplastic Thyroid carcinoma is an extremely aggressive solid tumor that resists most treatments and is almost always fatal. Galectin-3 (Gal-3) is an important marker for thyroid carcinomas and a scaffold of t...
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Article
Why anti-Bcl-2 clinical trials fail: a solution
The alteration in expression of B cell lymphoma-2 (Bcl-2) family of protein members in cancer is involved mainly in the regulation of apoptosis. Bcl-2 family proteins are currently used as major targets in the...
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Article
Galectin-3 regulates p21 stability in human prostate cancer cells
Galectin-3 (Gal-3) is a multifunctional protein involved in cancer through regulation of cell adhesion, cell growth, apoptosis and metastasis, while p21 (Cip1/WAF1) is a negative regulator of the cell cycle, i...
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Open AccessThe significance of galectin-3 as a new basal cell marker in prostate cancer
Prostate cancer may originate from distinct cell types, resulting in the heterogeneity of this disease. Galectin-3 (Gal-3) and androgen receptor (AR) have been reported to play important roles in the progressi...
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Open AccessCalpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment
Prostate cancer will develop chemoresistance following a period of chemotherapy. This is due, in part, to the acquisition of antiapoptotic properties by the cancer cells and, therefore, development of novel st...
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On the role of galectin-3 in cancer apoptosis
Galectin-3, a member of the β-galactoside-binding gene family, is a multifunctional protein implicated in a variety of biological functions, including tumor cell adhesion, proliferation, differentiation, angiogen...
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Article
Nutritional–pharmacological combinations
Recent studies have suggested that n–9 fatty acids in olive oil prevent colon carcinogenesis while n–6 PUFA seems to activate this process.
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Article
Open AccessHypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells
The incidence of distant metastases is higher in the tumours with low oxygen pressure than in those with high oxygen pressure. It is well known that hypoxia induces the transcription of various genes involved ...
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Expression and function of the AMF receptor by human melanoma in experimental and clinical systems
Motility of tumor cells is the rate limiting potential of metastatic cells and is regulated by autocrine and paracrine factors. Autocrine motility factor/neuroleukin/phosphohexose isomerase (AMF) is one of the...
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Article
Speech sounds learned by slee** newborns
It is not yet clear whether humans are able to learn while they are slee**1,2. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It...
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Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice
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Tumor Cell Motility
Surgery, chemotherapy and radiotherapy are the current modalities of tumor management. However, in systemic disease, predicted patients’ cure can be achieved in but a few tumor diseases. Based on previous basi...
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Article
Idiopathic non-obstructive hypertrophic cardiomyopathy, vitamin B12 deficiency and gastric adenocarcinoma: an unreported association in a teenager
A 14-year-old boy presented with anorexia and weakness whereon the diagnosis of dimorphic anaemia was made. An excellent response to iron and vitamin B12 was observed. In addition, the patient had non-obstructiv...
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Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer
Up-regulation of autocrine motility factor receptor (AMF-R) expression has been shown to be associated with invasion and metastasis of experimental tumour systems and human neoplasms. Monoclonal antibodies aga...
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Impact of community educational programmes on foreign body aspiration in Israel
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Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis
Active locomotion by invading tumor cells is thought to be a prerequisite step in the establishment of secondary neoplasms. Successful metastasis requires the invasion of surrounding normal tissue and crossing...
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Tumor cell motility—A novel therapeutic target in bladder cancer
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Effects of natural complex carbohydrate (citrus pectin) on murine melanoma cell properties related to galectin-3 functions
Citrus pectin (CP) and pH-modified citrus pectin (MCP) are highly branched and non-branched complex polysaccharides, respectively, rich in galactoside residues, capable of combining with the carbohydrate-bindi...
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Abstracts of papers presented at the 13th Conference of the Weed Science Society of Israel Abstracts of papers presented at the Third Israeli-Italian Phytopathological Symposium