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Chapter
Activation Of Protein Kinase C by 12(S)-HETE: Role in Tumor Cell Metastasis
Protein kinase C (PKC), the Ca2+ and phospholipid dependent kinase, belongs to the family of protein serine/threorine kinases (1). It is an important enzyme in mediating cell growth, cell differentiation and tumo...
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Chapter
Radiation Enhances Tumor Cell Metastasis
We previously reported that low dose photon radiation (i.e., γ and x-radiation) stimulates B16 melanoma cell anbβIIbβ3 integrin receptor expression (1). In studies reported here, we characterize radiation enhance...
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Chapter
Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis
Eicosanoids are a group of oxygenated arachidonic acid metabolites which include Prostaglandins, thromboxanes, leukotrienes, lipoxins, and various hydroperoxy and hydroxy fatty acids. Eicosanoids are implicate...