8 Result(s)
-
Chapter
Reversal of Ethanol Tolerance and Cross-Tolerance to Pentobarbital in the Rat
Adult male Wistar rats were fed nutritionally adequate liquid diets providing 35% of the total calories as ethanol, while pair-fed controls received the corresponding diet with ethanol replaced by an equicalor...
-
Chapter
Cross-Tolerance between Ethanol and Morphine
Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10–12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by a...
-
Chapter
Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates
Previously it has been shown that chronic administration of p-chlorophenylalanine (p-CPA), slowed the development of tolerance to ethanol, pentobarbital and cross-tolerance development to ethanol in rats chronica...
-
Chapter
Discussion
-
Chapter
Alcohol Withdrawal Syndromes in the Human: Comparison with Animal Models
Alcohol withdrawal syndromes in humans lie on a continuum of increasing severity, from the acute hangover to delirium tremens. Early mild reactions consist primarily of hyperexcitability phenomena such as trem...
-
Chapter
Comparative Aspects of Tolerance to, and Dependence on, Alcohol, Barbiturates and Opiates
Despite the known differences in mechanism of action of opiates and of the general depressants at molecular level, the withdrawal reactions after prolonged treatment with morphine, alcohol and barbiturates hav...
-
Chapter
Alcohol Induced Susceptibility to Hypoxic Liver Damage: Possible Role in the Pathogenesis of Alcoholic Liver Disease?
Previous studies in our laboratory (1–3), have indicated that the major rate limiting factor in ethanol metabolism in the intact liver cell is the rate of mitochondrial reoxidation to NAD+ of NADH produced in the...
-
Chapter
Biological Models of Alcohol Tolerance and Physical Dependence
Though tolerance to, and physical dependence on, ethanol have long been recognized, relatively little research has been devoted to the mechanisms by which these states are brought about. Comparatively, much mo...
