Research Advances in Alcohol and Drug Problems
Volume 5 / 1980 to Volume 11 / 1994
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Article
Dizocilpine prevents the development of tolerance to ethanol-induced error on a circular maze test
Dizocilpine [(+)MK-801] and ketamine, in doses that disrupt learning and memory, also prevent the development of tolerance to the motor impairing effects of ethanol (EtOH). However, dizocilpine itself affects ...
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Article
Loss of tolerance to morphine after a change in route of administration: control of within-session tolerance by interoceptive conditioned stimuli
Tolerance to morphine analgesia (tail-immersion test) was examined after manipulation of two aspects of a tolerance test: 1) the route of drug administration and 2) the time interval between the test dosing an...
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Book Series
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Book
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Article
Differential development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol
The development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol was examined. Acute tolerance to the motor impairment effect of ethanol was shown by a decrease in the degree of...
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Article
Influence of intoxicated practice on the development of acute tolerance to the motor impairment effect of ethanol
The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP inje...
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Article
Initial sensitivity, acute tolerance and alcohol consumption in fischer 344 and long evans rats
In separate groups of Fischer 344 and Long Evans rats, initial sensitivity and acute tolerance to ethanol were determined in a jum** test. Sensitivity measurements in each strain were carried out in separate...
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Article
Relationship between initial sensitivity, acute tolerance and chronic tolerance to ethanol in a heterogeneous population of Swiss mice
Acute and chronic tolerance to ethanol hypothermia as a function of the initial sensitivity were examined in a heterogeneous population of Swiss mice. Based on their day 1 hypothermic response to a challenge d...
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Article
Roles of intoxicated practice in the development of ethanol tolerance
The development of tolerance to the motor impairment effect of ethanol was examined in separate groups of rats receiving and not receiving intoxicated practice. Tolerance to the motor impairment effect of etha...
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Article
Tolerance to hyperthermia produced by morphine in rat
The present study addressed the prevailing notion that the rat develops tolerance only to the hypothermic effect of morphine and not to its hyperthermic effect. Rectal temperatures were measured at different i...
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Article
Role of Pavlovian conditioning in the development of tolerance and cross-tolerance to the hypothermic effect of ethanol and hydralazine
The role of Pavlovian conditioning in the development of tolerance to the hypothermic effect of ethanol and of cross-tolerance to hydralazine was investigated. In the first study, two groups of rats were treat...
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Article
Effect of raphe lesions on the development of chronic tolerance to pentobarbital and cross-tolerance to ethanol
Sham and electrolytic lesions of the dorsal, median, and median + dorsal raphe nuclei were made in different groups of rats, and the differential patterns of regional 5-HT depletion were verified chemically. O...
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Article
Differential sensitivity to ethanol, pentobarbital, and barbital in spontaneously hypertensive and normotensive Wistar-Kyoto rats
Ethanol, pentobarbital, and barbital sleep times and blood levels on awakening were determined in female spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WK) rats. Ethanol-induced sleep times wer...
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Article
Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance
Rats were permanently depleted of brain dopamine (DA), serotonin (5-HT), 5-HT+norepinephrine (NE), or NE +DA by intraventricular injection of either 5,7-dihydroxytryptamine (5,7-DHT) or 6-hydroxydopamine (6-OH...
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Article
Naloxone prevention of morphine LDR curve flattening associated with high-dose tolerance
Male wistar rats, previously made tolerant to morphine by at least 3 weeks of daily intraperitoneal (IP) injections of 20 mg/kg morphine-SO4 (MS), were then given 200 mg/kg MS daily for 4 or 5 days. Tail immersio...
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Article
Log dose/response curve flattening in rats after daily injection of opiates
Rats injected (IP) daily with 0, 20, and 200 mg/kg morphine-SO4 for 25–49 days experienced log dose/response (LDR) curve flattening (decrease in slope and/or maximum response) for analgesia (tail immersion test) ...
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Chapter
Reversal of Ethanol Tolerance and Cross-Tolerance to Pentobarbital in the Rat
Adult male Wistar rats were fed nutritionally adequate liquid diets providing 35% of the total calories as ethanol, while pair-fed controls received the corresponding diet with ethanol replaced by an equicalor...
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Chapter
Cross-Tolerance between Ethanol and Morphine
Adult male Wistar rats were fed chronically a liquid diet providing 35% of the calories as ethanol (10–12 g/kg ethanol daily), while pair-fed controls received the corresponding diet with alcohol replaced by a...
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Chapter
Role of Serotonin (5-Ht) in Tolerance to Ethanol and Barbiturates
Previously it has been shown that chronic administration of p-chlorophenylalanine (p-CPA), slowed the development of tolerance to ethanol, pentobarbital and cross-tolerance development to ethanol in rats chronica...
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Chapter
Discussion
