Abstract
Alcohol withdrawal syndromes in humans lie on a continuum of increasing severity, from the acute hangover to delirium tremens. Early mild reactions consist primarily of hyperexcitability phenomena such as tremor, insomnia, hyperreflexia and hyperventilation. In more severe degree, the same process gives rise to hallucinations and seizures. These early reactions are mimicked closely by alcohol withdrawal signs in experimental animals. Late reactions in humans are characterized by marked sympathetic nervous system overactivity, profound disorientation and hallucinations. Analogous reactions have not yet been observed clearly in other species. The problem may be one of finding appropriate techniques for detecting such changes, rather than a true species difference in their occurrence.
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References
Ellis, F. W., and Pick, J. R. Ethanol dependence in monkeys and dogs. In J. M. Singh, L. Miller and H. Lai (Eds.), Drug Addiction: Experimental Pharmacology, Vol. 1, pp. 293–300. Mount, Kisco, N.Y., Futura Publishing, 1971.
Essig, C. F. Barbiturate withdrawal in white rats. Int. J. Neuro-pharmacol., 5:103–108, 1966.
Essig, C. F., and Lam, R. C. Convulsions and hallucinatory behavior following alcohol withdrawal in the dog. Arch. Neurol. (Chicago), 18:626–632, 1968.
Fraser, H. F. Tolerance to and physical dependence on opiates, barbiturates and alcohol. Ann. Rev. Med., 8:427–440, 1957.
Fraser, H. F., Wikler, A., Essig, C. F., and Isbell, H. Degree of physical dependence induced by secobarbital or pentobarbital. J. Amer. Med. Ass., 166:126–129, 1958.
Freund, G. Alcohol, barbiturate, and bromide withdrawal syndrome in mice. In N. K. Mello and J. H. Mendelson (Eds.), Recent Advances in Studies of Alcoholism, pp. 453–471. Washington, U.S. Govt. Printing Office, 1971.
Fruensgaard, K. Withdrawal psychosis: a study of 30 consecutive cases. Acta Psychiat. Scand., 53:105–118, 1976.
Goldstein, D. B., and Pal, N. Alcohol dependence produced in mice by inhalation of ethanol; grading the withdrawal reaction. Science, 172:288–290, 1971.
Gross, M. M., Lewis, E., and Hastey, J. Acute alcohol withdrawal syndrome. In B. Kissin and H. Begleiter (Eds.), The Biology of Alcoholism, Vol. 3: Clinical Pathology, pp. 191–263, New York, Plenum Press, 1974.
Isbell, H., Fraser, H. F., Wikler, A., Belleville, R. E., and Eisenman, A. J. An experimental study on the etiology of “rum fits” and delirium tremens. Quart. J. Stud. Alc., 16:1–33, 1955.
Jaffe, J. H., and Sharpless, S. K. The rapid development of physical dependence on barbiturates. J. Pharmacol. Exp. Therap., 150:140–145, 1965.
Johnson, R. M. The alcohol withdrawal syndromes. Quart. J. Stud. Alc., Suppl. 1:66–76, 1961.
Majchrowicz, E. Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia (Berl.), 43:245–254, 1975.
Martin, W. R., Jasinski, D. R., Sapira, J. D., Flanary, H. G., Kelly, O. A., Thompson, A. K., and Logan, C. R. The respiratory effects of morphine during a cycle of dependence. J. Pharmacol. Exp. Therap., 162:182–189, 1968.
McQuarrie, D. G., and Fingl, E. Effects of single doses and chronic administration of ethanol on experimental seizures in mice. J. Pharmacol. Exp. Therap., 124:264–271, 1958.
Mello, N. K. A review of methods to induce alcohol addiction in animals. Pharmac. Biochem. Behav., 1:89–101, 1973.
Mendelson, J. H. (Ed.). Experimentally induced chronic intoxication and withdrawal in alcoholics. Quart. J. Stud. Alc., Suppl. 2: 1–126, 1964.
Rosenstein, R., McCarthy, L. E., and Borison, H. L. Respiratory effects of ethanol and procaine injected into the cerebrospinal fluid of the brainstem in cats. J. Pharmacol. Exp. Therap., 162:174–181, 1968.
Sellers, E. M., Zilm, D. H., MacLeod, S. M., Degani, N., and Giles, H. G. Chlordiazepoxide and propranolol treatment of alcoholic withdrawal. Clin. Res., 23:610a, 1975.
Sereny, G., and Kalant, H. Comparative clinical evaluation of chlordiazepoxide and promazine in treatment of alcohol-withdrawal syndrome. Brit. Med. J., 1:92–97, 1965.
Victor, M., and Adams, R. D. The effect of alcohol on the nervous system. Res. Publ. Ass. Res. Nerv. Ment. Dis., 32:526–573, 1953.
Waters, D. H., and Okamoto, M. Increased central excitability in non-dependent mice during chronic barbital dosing. In J. M. Singh, L. Miller and H. Lai (Eds.), Drug Addiction; Experimental Pharmacology, Vol. 1, pp. 199–209. Mount Kisco, N. Y., Futura Publishing, 1971.
Wikler, A., Pescor, F. T., Fraser, H. F., and Isbell, H. Electro-encéphalographic changes associated with chronic alcohol intoxication and the alcohol abstinence syndrome. Am. J. Psychiat., 113:106–114, 1956.
Wolfe, S. M., and Victor, M. The physiological basis of the alcohol withdrawal syndrome. In N. K. Mello and J. H. Mendelson (Eds.), Recent Advances in Studies of Alcoholism, pp. 188–199. Washington, U.S. Govt. Printing Office, 1971.
Zilm, D. H., Sellers, E. M., MacLeod, S. M., and Degani, N. Propranolol effect on tremor in alcoholic withdrawal. Ann. Intern. Med., 83:234–236, 1975.
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Kalant, H. (1977). Alcohol Withdrawal Syndromes in the Human: Comparison with Animal Models. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal—IIIb. Advances in Experimental Medicine and Biology, vol 85B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9038-5_5
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DOI: https://doi.org/10.1007/978-1-4615-9038-5_5
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