24 Result(s)
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Article
Yun-Wen Chen
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Open AccessDeficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze adenosine to inosine RNA editing. However, the functional role of...
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Potential alleviation of bone mineral density loss with Janus kinase inhibitors in rheumatoid arthritis
Rheumatoid arthritis (RA) is characterized by localized bone loss, general osteoporosis and increased fracture risks. Tumour necrosis factor inhibitors (TNFi), non-tumour necrosis factor inhibitors (non-TNFi) ...
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Appendicitis is associated with an increased risk of systemic lupus erythematosus: a nationwide, population-based, case–control study
To examine the association between appendicitis and the risk of systemic lupus erythematosus (SLE).
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Open AccessInvestigation of changes in ankylosing spondylitis disease activity through 2021 COVID-19 wave in Taiwan by using electronic medical record management system
We aim to investigate the alteration in disease activity of ankylosing spondylitis (AS) individuals before, during, and after the COVID-19 wave in Taiwan by using electronic medical-record management system (E...
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Open AccessHigh-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder an...
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Open AccessComparing the natural progression and clinical features of keratoconus between pediatric and adult patients
To present the natural course of keratoconus (KC) and compare pediatric and adult patients. Design A retrospective cohort study. Setting Hospital-based. Patient Population In total, 152 patients (288 eyes) diagno...
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Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein
Dual-specificity phosphatases (DUSPs) comprise a unique group of enzymes that dephosphorylate signaling proteins at both phospho-serine/threonine and phospho-tyrosine residues. Since Notch signaling is an esse...
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Open AccessHost CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli
Enterohemorrhagic Escherichia coli (EHEC) induces changes to the intestinal cell cytoskeleton and formation of attaching and effacing lesions, characterized by the effacement of microvilli and then formation of a...
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Open AccessAuthor Correction: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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The difference of surgical outcomes between manifest exotropia and esotropia
To determine the factors that affect ocular alignment and binocular sensory functions after strabismus surgery and compare surgical outcomes between manifest exotropia (XT) and esotropia (ET).
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Open AccessCorrection of hyperopia with astigmatism following radial keratotomy with daily disposable plus spherical contact lens: a case report
To report the refractive correction in a case of hyperopia and astigmatism following radial keratotomy.
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Factors associated with corneal epithelial defects after pars plana vitrectomy
To investigate the risk factors associated with corneal epithelial defects (CED) and delayed healing (exceeding 1 week) following pars plana vitrectomy (PPV).
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Open AccessSTIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
The clinical significance of STIM proteins and Orai Ca2+ channels in tumor progression has been demonstrated in different types of cancers. Podosomes are dynamic actin-rich cellular protrusions that facilitate ca...
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Open AccessSelective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed drugs for mood disorders. Long term use of SSRIs is associated with an increased risk of diabetes, but the underlying mechanism(...
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Open AccessEstrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel
Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. By comparing microglia and dopam...
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Open AccessThe STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition
Ca2+ signaling is important to trigger the cell cycle progression, while it remains elusive in the regulatory mechanisms. Here we show that store-operated Ca2+ entry (SOCE), mediated by the interaction between ST...
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Glucose regulates amyloid β production via AMPK
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. Accumulation of Aβ peptides in the brain has been suggested as the cause of AD (amyloid cascade hypothesis); however, the mechanism ...
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Open AccessProbing Hydrophilic Interface of Solid/Liquid-Water by Nanoultrasonics
Despite the numerous devoted studies, water at solid interfaces remains puzzling. An ongoing debate concerns the nature of interfacial water at a hydrophilic surface, whether it is more solid-like, ice-like, o...
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A molecular dynamics study on opioid activities of biphalin molecule
Molecular dynamics simulations of the biphalin molecule, (Tyr-D-Ala-Gly-Phe-NH)2, and the active tetrapeptide hydrazide, Tyr-D-Ala-Gly-Phe-NH-NH2 were performed to investigate the cause of the increased μ and δ r...
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Open AccessGene discovery using next-generation pyrosequencing to develop ESTs for Phalaenopsis orchids
Orchids are one of the most diversified angiosperms, but few genomic resources are available for these non-model plants. In addition to the ecological significance, Phalaenopsis has been considered as an economic...
