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Article
Open AccessYAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions
Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, h...
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Article
Open AccessThe HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate
Human HLTF participates in the lesion-bypass mechanism through the fork reversal structure, known as template switching of post-replication repair. However, the mechanism by which HLTF promotes the replication...
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Article
Open AccessPathophysiological implications of hypoxia in human diseases
Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nuc...
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Article
Open AccessChemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions
Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Fo...
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Open AccessAuthor Correction: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessA thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish
Thrombomodulin (TM), an integral membrane protein, has long been known for its anticoagulant activity. Recent studies showed that TM displays multifaceted activities, including the involvement in cell adhesion...
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Article
Correction: Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration
The original version of this article contained error in Fig. 6b, where several panels were missing from the published version. The corrected version of this Figure now appears in the article.
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Article
Open AccessSrc and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration
Vimentin intermediate filaments (VIFs), expressed in most mesenchymal and cancer cells, undergo dramatic reorganization during cell migration; however, the mechanism remains obscure. This study demonstrates th...
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Article
Open AccessBcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis
Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2...
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Article
Open AccessBiogenesis of podosome rosettes through fission
Podosomes are dynamic actin-based membrane protrusions that are important for extracellular matrix degradation and invasive cell motility. Individual podosomes are often found to organize into large rosette-li...
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Article
Open AccessSTIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion
The clinical significance of STIM proteins and Orai Ca2+ channels in tumor progression has been demonstrated in different types of cancers. Podosomes are dynamic actin-rich cellular protrusions that facilitate ca...
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Article
Open AccessChronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways
The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is ...
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Article
Open AccessThe STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition
Ca2+ signaling is important to trigger the cell cycle progression, while it remains elusive in the regulatory mechanisms. Here we show that store-operated Ca2+ entry (SOCE), mediated by the interaction between ST...
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Article
Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis
Pancreatic β-cells are particularly susceptible to fatty-acid-induced endoplasmic reticulum (ER) stress and apoptosis. To understand how β-cells sense fatty acid stimuli and translate into a long-term adaptive...
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Article
Open AccessRemodeling of calcium signaling in tumor progression
Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...
