43 Result(s)
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Article
Toshikazu Nakamura
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Article
Open AccessOrbital hybridization of donor and acceptor to enhance the conductivity of mixed-stack complexes
Mixed-stack complexes which comprise columns of alternating donors and acceptors are organic conductors with typically poor electrical conductivity because they are either in a neutral or highly ionic state. T...
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Recent Developments in Electron Spin Science and Technology in Japan
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Open AccessTryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-d...
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Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammator...
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Open AccessExpression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell diff...
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NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells
Hepatocyte growth factor (HGF) plays a definitive role in invasive, angiogenic, and metastatic activities of tumor cells by binding to the c-Met receptor. NK4, a competitive antagonist for HGF and the c-Met re...
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Characterization of the Enhancing Effect of Protamine on the Proliferative Activity of Hepatocyte Growth Factor in Rat Hepatocytes
The aim of the present study was to characterize the mechanism of the stimulatory effect of protamine on HGF activity.
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Open AccessTryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
Although nutrients, including amino acids and their metabolites such as serotonin (5-HT), are strong modulators of anxiety-related behavior, the metabolic pathway(s) responsible for this physiological modulati...
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Microfabricated airflow nozzle for microencapsulation of living cells into 150 micrometer microcapsules
Microencapsulation of genetically engineered cells has attracted much attention as an alternative nonviral strategy to gene therapy. Though smaller microcapsules (i.e. less than 300 μm) theoretically have vari...
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EPR Study of the Electronic States of β’-(BEDT-TTF)(TCNQ)
β’-(BEDT-TTF)(TCNQ) is a compound of BEDT-TTF (=ET) and TCNQ molecules aligned orthogonally with each other, forming two-dimensional sheets and one-dimensional columns of 1/4-filled π band, respectively. It is...
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Redistribution of Electronic Charge in (TMTTF)2ReO4: 13C NMR Investigation
13C NMR measurements were performed for one-dimensional organic conductors, (TMTTF)2ReO4. An intermediate charge-ordering (CO) phase has been found firstly for a TMTTF salt with a Td-symm...
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Article
EPR study of the electronic states of β′-(BEDT-TTF)(TCNQ)
β′-(BEDT-TTF)(TCNQ) is a compound of BEDT-TTF (=ET) and TCNQ molecules aligned orthogonally with each other, forming two-dimensional sheets and one-dimensional columns of 1/4-filled π band, respectively. It is...
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Article
Redistribution of electronic charge in (TMTTF)2ReO4:13C NMR investigation
13C NMR measurements were performed for one-dimensional organic conductors, (TMTTF)2ReO4. An intermediate charge-ordering (CO) phase has been found firstly for a TMTTF salt with a Td-symmetry cou...
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Therapeutic Angiogenesis Induced by Injecting Hepatocyte Growth Factor in Ischemic Canine Hearts
Therapeutic angiogenesis, induced by the direct injection of angiogenic growth factors or by transmyocardial laser revascularization (TMLR), has shown great potential as a new therapeutic strategy for end-stag...
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Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression
Peritoneal dissemination is the most common mode of metastasis in gastric cancer. We previously reported the importance of milky spots (MS), peritoneal lymphoid tissues, as selective sites of cancer implantati...
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Suppression of the Progress of Disseminated Pancreatic Cancer Cells by NK4 Plasmid DNA Released from Cationized Gelatin Microspheres
Purpose. NK4, composed of the NH2-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts as a potent angiogenesis inhibitor. This study is an investigation to evaluate the f...
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Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
Hepatocyte growth factor (HGF) is involved in malignant behavior of cancer cells by enhancing invasion and metastasis. We earlier found that NK4, a four-kringle fragment of HGF, functions as both an HGF antago...
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Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model
Gallbladder cancer cells are stimulated by hepatocyte growth factor (HGF) in vitro and in vivo. We constructed an adenovirus vector, AdCMV.NK4, carrying the HGF antagonist HGF/NK4 (NK4) and evaluated whether or n...
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Expression of hepatocyte growth factor and c-Met in the anterior horn cells of the spinal cord in the patients with amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS and familial ALS with superoxide dismutase 1 gene mutation
To clarify the trophic mechanism of residual anterior horn cells affected by sporadic amyotrophic lateral sclerosis (SALS) and familial ALS (FALS) with superoxide dismutase 1 (SOD1) mutations, we investigated ...
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Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats
Hepatocyte growth factor (HGF) is a unique growth factor with many protective functions. Previously, we demonstrated that HGF stimulated growth of endothelial cells without replication of vascular smooth musc...
