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Article
Open AccessCo-administration of FVIII with IVIG reduces immune response to FVIII in hemophilia A mice
Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major c...
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Article
Open AccessSystematic reviews of prognosis studies: a critical appraisal of five core clinical journals
Prognosis research refers to the investigation of association between a baseline health state, patient characteristic and future outcomes. The findings of several prognostic studies can be summarized in system...
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Article
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammator...
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Article
Open AccessHigh rate of spontaneous inhibitor clearance during the long term observation study of a single cohort of 524 haemophilia A patients not undergoing immunotolerance
The natural history of inhibitors in patients with haemophilia A not undergoing immune tolerance induction (ITI) is largely unknown. A recent randomized controlled trial suggests that the higher the FVIII dose...
